STUDIES ON DYNAMIC CHANGES AND COMPARISONS OF SERUM SPECIFIC IGM AND IGG ANTIBODIES IN PATIENTS WITH HEMORRHAGIC FEVER WITH R

ＬｉｕＺｈｅｎｇｗｅｎ（刘正稳）；ＺｈａｎｇＣｈｅｎｇｗｅｎ（张成文）；ＬｉｕＱｉｎｇｚｈｅｎ（刘清珍）；ＨａｎＳｕｘｉａ（韩苏夏）；ＷｕＳｕｇｅ（吴素歌）ＳＴＵＤＩＥＳＯＮＤＹＮＡＭＩＣＣＨＡＮＧＥＳＡＮＤＣＯＭＰＡＲＩＳＯＮＳＯＦＳＥＲＵＭＳＰＥ...

STUDIES ON DYNAMIC CHANGES AND COMPARISONS OF SERUM SPECIFIC IGM AND IGG ANTIBODIES IN PATIENTS WITH HEMORRHAGIC FEVER WITH RENAL SYNDROME

The speciric IgM and IgG antibodies in serum samples from patients with hemorrhagic fever with renal syndrome (HFRS) were sequentially and simultaneously determined during the course of the disease. The results showed that the detectable days and the days reaching 100% positive rate after onset of illness in specific IgM antibodies were earlier than those in specific IgG antibodies. No significant differences were observed between the titers of specific IgM antibodies on different days after onset of the disease while the titers of specific IgG antibodies differed, significantly on different days after onset of illness (F'= 11. 72,P< 0. 01 ). The titers of specific IgM antibodies in different clinical types were not significantly different at the same illness day but the titers of specific IgG antibodies in various clinical types were significantly different from day 7 to day 8 after onset of disease (F' = 4. 004, P< 0. 05). The levels of specific IgM and IgG antibodies were more stable and the crossings of the IgM and IgG antibody curves presented later in patients with mild and middle clinical types than those in patients with severe and gravis types. These results suggest that the detection of specific IgM antibodies may be useful for the early laboratory diagnosis of HFRS,the excess Production of specific IgG antibodies may play a role in the formation of immune complexes and the exacerbation of pathologic damage in patients with severe and gravis types and the observations of the dynamic changes of specific IgM and IgG antibody curves may have some implications in evaluating the seventies of the disease and the prognosis of the patients with HFRS.