| 促渗剂对盐酸小檗碱体外经皮渗透的影响 |
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| 引用本文： | 曾爱国,程秀云,王云彩,赵桂兰.促渗剂对盐酸小檗碱体外经皮渗透的影响[J].西安交通大学学报(医学版),2004,25(4):359-361,365. |
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| 作者姓名： | 曾爱国 程秀云 王云彩 赵桂兰 |
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| 作者单位： | 1. 西安交通大学药学院药剂研究室,陕西西安,710061
2. 陕西省渭南市中心医院药剂科,陕西渭南,714000 |
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| 摘 要： | 目的 研究几种促渗剂对盐酸小檗碱体外经皮渗透的影响。方法 在离体透皮实验装置上 ,以 30 % (体积分数 )乙醇作为接收液 ,观察盐酸小檗碱经大鼠腹部皮肤的渗透性 ,按规定时间取样 ,用高效液相色谱法 (HPLC)测定盐酸小檗碱的经皮渗透量。结果 几种促渗剂对盐酸小檗碱均有促渗透作用 ,不同透皮促渗剂促渗作用的大小顺序为 :氮酮 <丙二醇 <油酸 <冰片 <冰片 +丙二醇 <氮酮 +丙二醇 <油酸 +丙二醇。结论 氮酮、丙二醇、油酸、冰片、冰片 +丙二醇、油酸 +丙二醇、氮酮 +丙二醇均可作为促渗剂用于盐酸小檗碱的经皮吸收制剂。
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| 关 键 词： | 促渗剂 盐酸小檗碱 经皮渗透 |
| 文章编号： | 1671-8259(2004)04-0359-03 |
Influence of penetration enhancer on transdermal permeation of berberine hydrochloride in vitro |
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| Zeng Aiguo,Chen Xiuyun,Wang Yuncai,Zhao Guilan.Influence of penetration enhancer on transdermal permeation of berberine hydrochloride in vitro[J].Journal of Xi‘an Jiaotong University:Medical Sciences,2004,25(4):359-361,365. |
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| Authors: | Zeng Aiguo Chen Xiuyun Wang Yuncai Zhao Guilan |
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| Abstract: | Objective To study the effects of several enhancers on transdermal permeation of berberine hydrochloride. Methods The penetration rate of berberine hydrochloride through rat skin in 30% ethanol-water was measured using the penetration experiment apparatus. Samples were withdrawn from the receptor solution at certain time intervals and assayed by HPLC method. Results The penetration rate of berberine hydrochloride by the enhancers was increased in the following order: azone
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| Keywords: | penetration enhancer berberine hydrochloride percutaneous penetration |
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