精神分裂症患者性激素分泌变异的研究

为研究精神分裂症患者垂体促性腺激素及外周性激素的功能状态 ,探讨性激素水平改变与性有关症状和药物治疗的关系 ,采用放射免疫法测定 35例精神分裂症患者血清促卵泡激素 ( FSH)、黄体生成素 ( L H)、催乳素 ( PRL)、睾丸酮 ( T)、雌二醇 ( E2 )等激素水平 ,并与 2 0例正常人比较。结果显示 ,试验组中男性 E2 和女性FSH、LH水平显著低于对照组 ,男、女性 PRL水平显著高于对照组。按性有关症状的有、无分为两组 ,两组间性激素水平无显著性差异。药物治疗前、后男性 PRL、E2 改善明显 ,女性 FSH、PRL、T和 E2 改变非常显著。奋乃静、舒必利可致明显的高 PRL血症 ,但氯氮平无明显影响。提示精神分裂症患者性腺轴存在功能失调。性有关症状与性激素水平改变无关。抗精神病药物治疗可导致性激素分泌紊乱。

A STUDY OF SEX HORMONE ABNORMALITIES IN SCHIZOPHRENIC PATIENTS

In order to study the functional status of human pituitary gonadotropin and peripheral blood sex hormones, and the influence of antipsychotic drugs on those hormones in schizophrenic patients,FSH,LH, PRL , T and E 2 were tested in 35 schizophrenic patients and compared with 20 normal controls. The results showed that E 2 level in male and FSH, LH level in female schizophrenic patients were significantly lower than that in controls.PRL increased significantly in male and female patients.No correlation was found between sex related psychotric symptoms and significant change after treatment.PRL increased significantly after using trilafon and sulpirid, but clozapine not .It suggests that schizophrenia might have sex hormone dysfunction.The sex related psychotric symptoms are not related with the changes of sex hormone.Some kinds of antipsychotics treatment may induce the change of sex hormone secretion.