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Correlative factors of cognitive impairment in patients with lacunar infarcts I.
作者姓名:张秋娟  姚晓新  郭佑民  张格娟  杨军乐
作者单位:[1]Imaging Centre, the Second Affiliated Hospital, Medical School of Xi'an Jiaotong University, Xi'an 710004, China [2]Imaging Centre, the Fourth Hospital of Xi'an, Xi'an 710004, China
基金项目:This study was supported by Shaanxi Science Technology Study Development Plan Item (No. 2006K13-G7-6) and Xi'an Science Technology Study Development Plan Item (No. GG05140).
摘    要:Objective To study the relationships between cognitive impairment in patients with lacunar infarcts and quantitative CT measures and to determine the independent correlative factors of cognitive impairment. Methods Neuropsychological examination was conducted for 128 patients with acute lacunar infarct. Number, location, and volume of infarcts, cerebral atrophy index and severity of white matter lesions (WMLs) were measured and recorded. Results The number of lacunar infarcts in cognitive impairment (CI) group was significantly larger than that in cognitive normal (CN) group. Mean width of sulcns and sylvian fissure, index of frontal horn and ventricular-brain ratio (VBR) were significantly different in both groups. There were more patients with 3 grades or 4 grades WMLs in CI group (62%) than those in CN group (22%). The total volume of lacunar infarcts showed no statistically significant difference. Logistic regression analysis indicated that the number of lacunar infarcts in frontal subcortex and thalamus, the volume of infarcts in anterior periventricular white matter, width of cerebral sulcns and sylvian fissure were correlated with cognitive impairment respectively. Additionally, age and education were correlative factors of cognitive impairment in patients with lacunar infarct. Conclusion Correlative factors of cognitive impairment in patients with lacunar infarct are not merely one feature, but a combination of infarct features (number, location, and volume), cortical atrophy and host factors (age and education).

关 键 词:腔隙性脑梗死  认知功能损害  相关因素  CT
文章编号:1671-8267(2007)01-0086-05

Correlative factors of cognitive impairment in patients with lacunar infarcts I.
Zhang Qiujuan, Yao Xiaoxin , Guo Youmin , Zhang Gejuan , Yang Junle.Correlative factors of cognitive impairment in patients with lacunar infarcts I.[J].Academic Journal of Xi’an Jiaotong University,2007,19(1):86-90.
Authors:Zhang Qiujuan  Yao Xiaoxin  Guo Youmin  Zhang Gejuan  Yang Junle
Abstract:
Keywords:cognitive impairment  lacunar infarct  computed tomography  X-ray
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