| THE EXPERIMENTAL STUDY ON THE EFFECTS OF SIX MYCOTOXINS ON THE CULTURAL CHONDROCYTES |
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| 作者姓名： | 曹峻岭 熊咏民 李斯纯 郑滨 张矢远 毕华银 莫东旭 |
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| 作者单位： | Institute of Endemic Bone Diseases，Xi'an Medical University，Xi'an 710061 |
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| 摘 要： | ThisstudywassubsidizedbytheNiationalKeyProjects85-917-01-03and85-917-01-02AsanetiologicalstudyofKashinBeckdisease(KBD),thepoisoningofmycotoxinsisoneoftheimportanttheoriest12.ByfeedingchickenwithfoddercontainingfusariumofgrainfromKBDareas,itwasfoundthatchicken1.-esentedobviousretrogradeaffectioninthegrowthplateofkneeJoint.Thechondrocytesshowedgrowthhindrancewithdegenerativechanges,andtherewasaband--shapednecrosisinthegrowthcartilage">.Thefungiandmycotoxinswererepeatedlyexaminedinthegrainof…
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THE EXPERIMENTAL STUDY ON THE EFFECTS OF SIX MYCOTOXINS ON THE CULTURAL CHONDROCYTES |
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| Cao Junling,Xiong Yongmin,Li Sichun,Zheng Bin,Zhang Shiyuan,Bi Huayin,Mo Dongxu.THE EXPERIMENTAL STUDY ON THE EFFECTS OF SIX MYCOTOXINS ON THE CULTURAL CHONDROCYTES[J].Academic Journal of Xi’an Jiaotong University,1998(1). |
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| Authors: | Cao Junling Xiong Yongmin Li Sichun Zheng Bin Zhang Shiyuan Bi Huayin Mo Dongxu |
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| Abstract: | The effects of deoxynlvalenol (DON), T--2 toxin, nivalenol (NIv), hutenolide (BuT).alternariol methyl ether(AME) and monlliformin (cON ) on rabbit articular chondrocytes were observed by using the method of chondrocyte monolayer culture. The amounts or DNA in chondrocytesand glucuronate in matrix were measured. And the chondrocytes were observed by inversion microscope and transmission electron microscope (TEM). The results showed that the cultured chondrocytes were damaged by all the six mycotoxinsl and the synthesis of DNA and the divided reproductionof chondrocytes were restrained; the damage errect was more evident, esl,ecially in the early stage ofculturel the higher concentration or toxin in the media was used, the lower density of the culturalckondrocytes was observed; the cells were even round damaged and dead, so long as the media contolued toxin. When the six mycotoxins arrected the cultural chondrocytes r.spectively, three dirfereut kinds or ultrastructural changes in ckondrocytes were seen by TEa. The relationship betweenmycotoxiu and KBD was preliminarily discussed, and some problems still need further investigation.. |
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| Keywords: | chondrocyte culture deoxynivalenol T-2 toxin nivalenol butenolide alternariol methyl ether moniliformin Kashin-Beck disease |
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