Bcl-2蛋白在肺癌组织中的表达及其意义 |
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引用本文: | 温雪萍,程西安,王有恒,苏宝山. Bcl-2蛋白在肺癌组织中的表达及其意义[J]. 西安交通大学学报(医学版), 2001, 22(1): 41-42 |
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作者姓名: | 温雪萍 程西安 王有恒 苏宝山 |
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作者单位: | 1. 上海瑞金集团闵行医院 2. 铜川市人民医院内科, 3. 西安交通大学第二医院病理科 |
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摘 要: | 目的 探讨bcl 2蛋白在肺癌发生、发展中的作用。方法 采用免疫组化SP法检测了 56例肺癌组织中bcl 2蛋白的表达。结果 肺癌组织中bcl 2蛋白表达率为 50 0 % ,癌旁组织为72 2 % ,差异无显著性 (P >0 0 5) ,但二者均明显高于正常肺组织 (6 7% ,P <0 0 5) ,bcl 2过表达与肺癌病理类型、分化程度均无关 (P >0 0 5) ,与TNM分期呈负相关 (P <0 0 5)。结论 bcl 2过表达与肺癌发生有关 ,可能为细胞发生恶性转化的早期信号。
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关 键 词: | bcl-2蛋白 肺肿瘤 免疫组织化学 |
文章编号: | 0258-0659(2001)01-0041-02 |
修稿时间: | 2000-09-25 |
Expression and clinicalsignificances of bcl-2 protein in lung cancer |
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Abstract: | Objective To investigate the function of bcl 2 protein in genesis and development of lung cancer.Methods Expressions of bcl 2 protein in 56 patients with lung cancer were examined by immunohoistochemical S P method.Results The expression rates of bcl 2 protein were 50.0% in lung cancer tissues and 72.2% in adjacent non neoplastic tissues.There was no significant difference in the former,but either of them was distinctly higher than that in normal lung tissues ( P <0.05),overexpression of bcl 2 protein was not associated with pathological types and differential grades of lung cancer ( P >0.05),but was negative related to P TNM stages ( P <0.05).Conclusion Overexpression of bcl 2 protein is related to lung carcinogenesis and may be an early signal of cell malignant transformation. |
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Keywords: | bcl 2 protein lung neoplasms immunohistochemistry |
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