| THE MORPHOLOGICAL CHANGES IN MUSCLE SPINDLES AND ALTERATIONS IN CELL ACTIVITY OF THE RATS'''' RED NUCLEUS AFTER 2 WEEKS'''' SIMULATED WEIGHTLESSNESS |
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| 引用本文： | 朱永进,樊小力,吴苏娣,李强. THE MORPHOLOGICAL CHANGES IN MUSCLE SPINDLES AND ALTERATIONS IN CELL ACTIVITY OF THE RATS'''' RED NUCLEUS AFTER 2 WEEKS'''' SIMULATED WEIGHTLESSNESS[J]. 西安交通大学学报(英文版), 2006, 18(2) |
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| 作者姓名： | 朱永进 樊小力 吴苏娣 李强 |
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| 作者单位： | Department of Physiology Medical School of Xi'an Jiaotong University Key Laboratory of Environment and Genes Related to Diseases of Ministry of Education Xi'an Jiaotong University Xi'an 710061 China，Department of Physiology Medical School of Xi'an Jiaotong University Key Laboratory of Environment and Genes Related to Diseases of Ministry of Education Xi'an Jiaotong University Xi'an 710061 China，Department of Physiology Medical School of Xi'an Jiaotong University Key Laboratory of Environment and Genes Related to Diseases of Ministry of Education Xi'an Jiaotong University Xi'an 710061 China，Department of Physiology Medical School of Xi'an Jiaotong University Key Laboratory of Environment and Genes Related to Diseases of Ministry of Education Xi'an Jiaotong University Xi'an 710061 China |
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| 摘 要： | The extensive negative effects induced by zerogravity or microgravity where offer special environ-ment are har mful for cos monauts[1-3].The real spaceenvironment has many characteristics,including mi-crogravity,electromagnetic fields,and radiation,which may have an effect on the function and mor-phology of the CNS[4],but the changes in CNSin-duced by si mulated weightlessness on the groundcaused the corresponding adaptive changes of cere-bral circulation,which made alterations in sensoryper…
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THE MORPHOLOGICAL CHANGES IN MUSCLE SPINDLES AND ALTERATIONS IN CELL ACTIVITY OF THE RATS'''' RED NUCLEUS AFTER 2 WEEKS'''' SIMULATED WEIGHTLESSNESS |
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| Zhu Yongjin,Fan Xiaoli,Wu Sudi,Li Qiang. THE MORPHOLOGICAL CHANGES IN MUSCLE SPINDLES AND ALTERATIONS IN CELL ACTIVITY OF THE RATS'''' RED NUCLEUS AFTER 2 WEEKS'''' SIMULATED WEIGHTLESSNESS[J]. Academic Journal of Xi’an Jiaotong University, 2006, 18(2) |
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| Authors: | Zhu Yongjin Fan Xiaoli Wu Sudi Li Qiang |
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| Abstract: | Objective To study the morphological changes of soleus muscle spindle and electrical activity of neurons in Red Nucleus(RN) of the rat after 2 weeks' simulated weightlessness, and to reveal the interaction between proprioceptive inputs of muscle spindles and reciprocal alterations in RN under simulated weightlessness. Methods Twenty female rats were exposed to weightlessness simulated by tail-suspension for 14 days (SW-14d). Body weight(200-220g) matched female rats were control group(Con). The morphological changes in isolated muscle spindle of soleus muscle, the discharges of red nucleus neurons were observed after 14d tail-suspensions by silver staining and extracellular recording respectively. Results Compared with control group ,the nerve ending of muscle spindle in SW-14d was distorted, degenerated and dissolved; the diameters of intrafusal fibers and capsule in equatorial region of soleus muscle spindles were diminished(P＜0.05). The spontaneous cell activity and discharge of RN neurons (spikes/s) induced by afferent firing from muscle spindles after injection of succinylcholine were reduced after 2 weeks' simulated weightlessness respectively (18.44±5.96 vs. 10.19±6.88, 32.50±8.08 vs. 16.86±5.97, P＜0.01). Conclusion The degeneration of muscle spindle induced by simulated weightlessness may be one of the causes that led to alterations in discharges of RN. |
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| Keywords: | simulated weightlessness muscle spindles red nucleus electrophysiology |
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