| 银屑病患者初发皮损中单个核细胞的观察 |
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| 引用本文： | 任建,马元起,司履生.银屑病患者初发皮损中单个核细胞的观察[J].西安交通大学学报(医学版),1990(4). |
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| 作者姓名： | 任建 马元起 司履生 |
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| 作者单位： | 西安医科大学第一附属医院皮肤病学教研室
(任建，马元起)，西安医科大学病理解剖学教研室(司履生) |
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| 摘 要： | 用单克隆抗体、ABC法对10例寻常型泛发性进行期银屑病患者初发皮损中单个核细胞进行分析,发现初发皮损内增多的单个核细胞以T淋巴细胞为主,巨噬细胞次之,并且大部分呈DR~+,未见B淋巴细胞,表皮内DR~+树枝状细胞和DR~+角朊细胞常与其周斟DR~+T淋巴细胞位置很接近,说明银屑病的发生与细胞免疫紊乱密切相关。
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| 关 键 词： | 银屑病 初发皮损 淋巴细胞亚群 |
OBSERVATION OF MONONUCLEAR CELLS IN EARLY SKIN LESIONS OF PATIENTS WITH PSORIASIS |
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| Ren Jian,Ma Yuanqi,Si Lisheng.OBSERVATION OF MONONUCLEAR CELLS IN EARLY SKIN LESIONS OF PATIENTS WITH PSORIASIS[J].Journal of Xi‘an Jiaotong University:Medical Sciences,1990(4). |
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| Authors: | Ren Jian Ma Yuanqi Si Lisheng |
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| Abstract: | The mononuclear cells in early skin lesions of 10 patients with extensive psoriasis vulgaris in progressive stage were studied by biotin-avidin-peroxidase method using monoclonal antibodies. The results show that increased mononuclear cells in the early skin lesions, expressing HLA-DR antigen mostly, consist of T lymphocytes and macrophases with a preponderance of T lymphocytes, B lymphocytes are absent, activated T lympocytes are usually in close proximity to DR~+ cells including dentritic cells and keratinocytes, indicating that the initial psoriatic lesion correlates closely with imbalance of cellular immunity. |
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| Keywords: | psoriasis early skin lesion lymphocyte subsets |
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