| THE EFFECT OF LIGUSTRAZINE ON NEUROGENESIS IN CORTEX AFTER FOCAL CEREBRAL ISCHEMIA IN RATS |
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| 引用本文： | 邱芬 刘勇 张蓬勃 康前雁 田英芳 陈新林 赵建军 祁存芳. THE EFFECT OF LIGUSTRAZINE ON NEUROGENESIS IN CORTEX AFTER FOCAL CEREBRAL ISCHEMIA IN RATS[J]. 西安交通大学学报(英文版), 2006, 18(1): 68-72 |
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| 作者姓名： | 邱芬 刘勇 张蓬勃 康前雁 田英芳 陈新林 赵建军 祁存芳 |
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| 作者单位： | [1]Research Center for Neuroscience , Department of Human Anatomy, Histology and Embryology, X i ＇anJiaotong University School of Medicine, Xi＇an 710061, China. [2]Editorial Board of Journal of Xi＇an Jiaotong University （Medicai Sciences）, Department of Human Anatomy, Histology and Embryology, X i ＇anJiaotong University School of Medicine, Xi＇an 710061, China. |
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| 摘 要： | Objective To explore the effect of Ligustrazine on neurogenesis in cortex after focal cerebral ischemia in rats. Methods Focal cerebral ischemia was induced by left middle cerebral artery occlusion with a suture. Two hours later, injection of Ligustrazine （80 mg/kg, 1 time/d） was performed peritoneally. Four hours after the ischemia, 5-bromodeoxyuridine （BrdU） （50 mg/kg, 1 time/d） was injected peritoneally. At 7 d, 14 d and 21 d after ischemia, BrdU positive cells in the cortex were observed by cal staining. Results In ischemic model group, at 7 day, sparsely-distributed BrdU positive cells were observed in the Ⅱ-- Ⅵ layers of the ipsilateral cortex, with a bandlike distribution in ischemic penumbra. With the prolongation of ischemia, the number of BrdU positive cells increased. In Ligustrazine group, BrdU positive cells were also observed in theⅡ-- Ⅵ layers of the cortex, with an intense distribution in ischemic penumbra. The numbers of BrdU positive cells at 7 d, 14 d and 21 d were more than those in ischemic model group respectively. Conclusion Ligustrazine increases the proliferated cells in cortex after focal cerebral ischemia in rats. The results suggest that it may be useful for promoting self-repair after ischemia.
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| 关 键 词： | 川芎嗪 神经发生 神经形成 大脑缺血 |
| 文章编号： | 1671-8267（2006）01-0068-05 |
THE EFFECT OF LIGUSTRAZINE ON NEUROGENESIS IN CORTEX AFTER FOCAL CEREBRAL ISCHEMIA IN RATS |
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| Qiu Fen,Liu Yong,Zhang Pengbo,Kang Qianyan,Tian Yingfang,Chen Xinlin,Zhao Jianjun,Qi Cunfang. THE EFFECT OF LIGUSTRAZINE ON NEUROGENESIS IN CORTEX AFTER FOCAL CEREBRAL ISCHEMIA IN RATS[J]. Academic Journal of Xi’an Jiaotong University, 2006, 18(1): 68-72 |
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| Authors: | Qiu Fen Liu Yong Zhang Pengbo Kang Qianyan Tian Yingfang Chen Xinlin Zhao Jianjun Qi Cunfang |
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| Abstract: | Objective To explore the effect of Ligustrazine on neurogenesis in cortex after focal cerebral ischemia in rats. Methods Focal cerebral ischemia was induced by left middle cerebral arteryocclusion with asuture. Two hours later, injection of Ligustrazine (80 mg/kg, 1 time/d) was performed peritoneally. Four hours after the ischemia,5-bromodeoxyuridine (BrdU) (50 mg/kg, 1 time/d) was injected peritoneally. At 7 d, 14 d and 21 d after ischemia,BrdU positive cells in the cortex were observed by immunohistochemical staining. Results In ischemic model group, at 7 day, sparsely-distributed BrdU positive cells were observed in the Ⅱ - Ⅵ layers of the ipsilateral cortex, with a band-like distribution in ischemic penumbra. With the prolongation of ischemia, the number of BrdU positive cells increased.In Ligustrazine group, BrdU positive cells were also observed in the Ⅱ - Ⅵ layers of the cortex, with an intense distribution in ischemic penumbra. The numbers of BrdU positive cells at 7 d, 14 d and 21 d were more than those in ischemic model group respectively. Conclusion Ligustrazine increases the proliferated cells in cortex after focal cerebral ischemia in rats. The results suggest that it may be useful for promoting self-repair after ischemia. |
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| Keywords: | ligustrazine cerebral ischemia neurogenesis cortex penumbra |
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