| 骨髓移植患者和献血员巨细胞病毒特异性抗体的检测及其意义 |
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| 引用本文： | 张梅,刘陕西,邵文斌,蔡瑞波,郭桂丽.骨髓移植患者和献血员巨细胞病毒特异性抗体的检测及其意义[J].西安交通大学学报(医学版),1995(2). |
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| 作者姓名： | 张梅 刘陕西 邵文斌 蔡瑞波 郭桂丽 |
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| 作者单位： | 第一附属医院血液病研究室 西安710061 |
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| 摘 要： | 用酶联免疫吸附法检测了5例骨髓移植病人,204名献血员巨细胞病毒特异性抗体IgM和IgA,结果5名接受骨髓移植的病人全部阴性,204名献血员中总抗体检出率29.91％,表明西安地区部分献血员中巨细胞病毒感染率较高,且为近期或活动性感染。这将对骨髓移植构成极大的危险。因此在骨髓移植中应筛选巨细胞病毒抗体阴性的献血员。
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| 关 键 词： | 骨髓移植 巨细胞病毒（CMV） 抗体 献血员 |
DETERMINATION OF THE SPECIFIC ANTIBODIES TO CYTOMEGALOVIRUS IN THE PATIENTS WITH BONE MARROW TRANSPLANTATION AND BLOOD DONORS |
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| Zhang Mei,Liu Shaanxi,Shao Wenbin. et al.DETERMINATION OF THE SPECIFIC ANTIBODIES TO CYTOMEGALOVIRUS IN THE PATIENTS WITH BONE MARROW TRANSPLANTATION AND BLOOD DONORS[J].Journal of Xi‘an Jiaotong University:Medical Sciences,1995(2). |
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| Authors: | Zhang Mei Liu Shaanxi Shao Wenbin |
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| Abstract: | One of the most dangerous complications in BMT is interstitial pneumonia which is the result of cytomegalovirus infection. We used en-zymelinked immunosorbant assay (indirect ELISA) to determine the specific antibodies of IgM and IgA to cytomegalovirus in 5 patients with BMT and 204 blood donors before transfusion, the antibodies de-tected were negative in 5 patients and 29.91% positive in blood donors. This result suggested that there were a higher infection rate and active or recent infection of cytomegalovirus in the patients with BMT. So it is nessesary to screen negative CMV antibody blood from donors for bone marrow transplantation. |
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| Keywords: | bone marrow transplantation (BMT) cytomegalovirus(CMV) antibodies blood donors |
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