494例甲状腺癌分布特征及诊断方法评价

目的　研究我省甲状腺癌的分布、诊断、治疗状况 ,评价其诊断方法并为该病生存分析提供基础资料。方法　收集 1 985年 1月至 1 999年 4月两所省级及医学院附属医院全部住院治疗的甲状腺癌病患者 494例及部分良性甲状腺肿瘤患者 2 2 3例的临床资料。结果　 494例甲状腺癌患者中以乳头状癌最多占 6 1 5 % ,其他组织类型依次为滤泡状癌 (2 3 1 % ) ,未分化癌(8 9% ) ,髓样癌 (6 5 % )。甲状腺癌发病年龄较其他癌偏低 ,除未分化癌其他均女性高于男性。以病理检查结果为标准评价细针穿吸及同位素检查 ,前者灵敏度为 85 2 % ,特异度为 85 7% ;后者灵敏度为 87 8% ,特异度为 2 5 0 %。结论　甲状腺癌在本省的分布与以往资料相似。细针穿吸法灵敏度和特异度均较高 ,而同位素法灵敏度与细针穿吸法相近 ,特异度较低。

Distribution characteristics and evaluation of diagnostic methods in 494 thyroid cancerpatients

ObjectiveTo study the distribution and the st atus of diagnosis and therapy of thyroid cancer patients in Shaanxi Province and evaluate the diagnostic methods and to obtain the basic data for survival analy sis of thyroid cancer.MethodsThe clinical data of 494 thyroid cancer inpatients and 223 benign thyroid tumor patients were collected from two hospitals' records from Jan 1985 to Apr 1999.ResultsThe percentage of papillary cancer was the highest(61.5 %) next were follicular, undifferentiated and medullary carcinoma in the order. The age of onset was younger than the other cancers. Thyroid cancer was more com mon in females of all histopathologic patients excepting undifferentiated carici noma. The sensitivity of fine needle aspiration biopsy was 85.2%, specificity w as 85.7%; the sensitivity of radioisotope scanning was 87.8% and specificity was 25.0%.ConclusionThe distribution of thyroid cancer in Shaanxi Provin ce is similar to the previous studies. Both sensitivity and specificity of fine needle aspiration biopsy are high, the sensitivity of radioisotope scanning is s imilar to needle aspiration but the specificity is much lower.