| 2型糖尿病患者血浆内皮素水平及影响因素的探讨 |
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| 引用本文： | 何岚,马秀萍,董治平,樊新华,赵惠珍.2型糖尿病患者血浆内皮素水平及影响因素的探讨[J].西安交通大学学报(医学版),1999(2). |
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| 作者姓名： | 何岚 马秀萍 董治平 樊新华 赵惠珍 |
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| 作者单位： | Department of Internal Medicine，First Affiliated Hospital |
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| 摘 要： | 我们用ＲＩＡ法测定了９０例２型糖尿病患者血浆中内皮素（ＥｎｄｏｔｈｅｌｉｎＥＴ）水平，观察了ＥＴ与糖代谢、脂代谢及糖尿病病程、血压、糖尿病慢性并发症的关系，以便了解ＥＴ在糖尿病慢性并发症中的作用，从而探讨糖尿病慢性并发症的发生机制。结果发现无合并症２型糖尿病组ＥＴ水平与正常对照组无显著性差异（Ｐ＞０．０５），有合并症Ⅱ型糖尿病组ＥＴ水平显著高于无合并症２型糖尿病组及正常对照组（Ｐ＜０．００１）。长病程、高血压、高胆固醇血症及糖尿病肾病是导致２型糖尿病患者血浆ＥＴ升高的主要因素，而ＥＴ升高又进一步加重糖尿病血管功能异常，从而加重糖尿病的慢性并发症。
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| 关 键 词： | 内皮素 2型糖尿病 糖尿病慢性并发症 |
SERUM LEVELS OF ENDOTHELIN IN PATIENTS WITH TYPE 2 DIABETES MELLITUS AND THE INFLUENCING FACTORS |
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| He Lan,Ma Xiuping,Dong Zhiping et al.SERUM LEVELS OF ENDOTHELIN IN PATIENTS WITH TYPE 2 DIABETES MELLITUS AND THE INFLUENCING FACTORS[J].Journal of Xi‘an Jiaotong University:Medical Sciences,1999(2). |
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| Authors: | He Lan Ma Xiuping Dong Zhiping |
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| Abstract: | We used immunoradioassay analysis to examine the plasma concentration of endothelin(ET) in 26 healthy controls and 90 type 2 diabetes mellitus .The results indicates that ET levels in patients with DMCC are significantly higher than patients without DMCC and controls.No significant difference of ET levels is observed between patients without DMCC and controls.The long course of disease,hypertension, hypercholesterolemia and diabetic nephropathy are the important factors that can lead to the increase of ET in type 2 diabetes mellitus. |
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| Keywords: | endothelin(ET) type 2 diabetes mellitus diabetes mellitus chronic complication(CMCC) |
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