Fine Mapping of a Deafness Mutation hml on Mouse Chromosome 10

Objective To map a mouse deafness gene.identify the underlying mutation and develop a mouse model for human deafncss.Methods Genetic lindage cross and genome scan wer used to map a novel mutation named hypoplasia of the membranous labyrinth (hml),which causes hearing loss in mutant mice.Results ① hml was mapped on mouse Chr 10 (～43 cM from the centromere) suggests that the homologous human gene is on 12q22--q24, which was defined on the basis of known mouse-human homologies (OMIM,2004). ② This study has generated 25 polymorphic microsateUite markers, placed 3 known human genes in the correct order in a high-resolution mouse map and narrowed the hml candidate gene region to a 500 kb area.     

NETWORK MANAGEMENT WITH SECURED MOBILE AGENT

IntroductionMobile Agents equipped with intelligence,of-fer new technology that helps automate NetworkManagement activities,which are increasingly be-coming complex due to exponential growth of in-ternet users,and thus demanding higher levels ofhuman manager expertise and involvement.Well-known network management protocols that areused to monitor and manage network devices in-clude Simple Network Management Protocol ( SN-MP) and Common Management Information Proto-col ( CMIP) ,SNMP be…     

TRANSCRIPTION ACTIVATION BY HBV PRE SI PROTEIN

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IP ADDRESS AUTOCONFIGURATION FOR WIRELESS AD HOC NETWORKS

IntroductionWireless ad hoc networks are gaining increas-ing popularity in recent years because of their easeof deployment. No wired base station or infras-tructure is supported,and each hostcommunicatesone anothervia packetradios. In ad hoc networks,routing protocols are challenged with establishingand maintaining multihop routes in the face of mo-bility,bandwidth limitation and power con-straints. In ad hoc networks,each node( host)acts as a router since routes are mostly multihop.Nodes in …     

Galvanic corrosion behaviour of HE 20 / MDN 138 & HE 20 / MDN 250 alloys in natural seawater

In view of their excellent mechanical properties, workability and heat treatment characteristics, MDN 138 & MDN 250 have been widely used in missile, rocket and aerospace industries. With light weight and high performance characteristics HE 20 aluminium alloy acts as an important material in defence and aerospace applications. The galvanic corrosion behaviour of the metal combinations HE 20 / MDN 138 and HE 20 / MDN 250, with 1:1 area ratio, has been studied in natural seawater using the open well facility of CECRI’s Offshore Platform at Tuticorin for a year. The open circuit potentials of MDN 138, MDN 250 and HE 20 of the individual metal, the mixed potential and galvanic current of the couples HE 20 / MDN 138 and HE 20 / MDN 250 were periodically monitored throughout the study period. The calcareous deposits on MDN 138 and MDN 250 were analysed using XRD. The results of the study reveal that that HE 20 has offered required amount of protection to MDN 138 & MDN 250.     

Modification of the Highway Capacity Manual two‐lane highway analysis procedure for Spanish conditions

The US Highway Capacity Manual (HCM) methodology is used in Spain to evaluate traffic operation and quality of service. The effect of passing manoeuvre on two‐lane highway operational performance is considered through adjustment factors to average travel speeds and percent time spent following. The procedure is largely based on simulations in TWOPAS and passing behaviours observed during US calibrations in the 1970s. It is not clear whether US driving behaviour and vehicles' performance are comparable with Spanish conditions. The objective of this research is to adapt the HCM 2010 methodology to Spanish driver behaviour, for base conditions (i.e. no passing restrictions). To do so, TWOPAS was calibrated and validated based on current Spanish passing field data. The calibration used a genetic algorithm. The case study included an ideal two‐lane highway with varying directional traffic flow rate, directional split and percentage of trucks. The updated methodology for base conditions is simpler than the current HCM 2010 and does not rely on interpolation from tables. Copyright © 2016 John Wiley & Sons, Ltd.     

Finding time‐robust fuel‐efficient paths for a call‐taxi in a stochastic city road network

Intra‐city commuting is being revolutionized by call‐taxi services in many developing countries such as India. A customer requests a taxi via phone, and it arrives at the right time and at the right location for the pick‐up. This mode of intra‐city travel has become one of the most reliable and convenient modes of transportation for customers traveling for business and non‐business purposes. The increased number of vehicles on city roads and raising fuel costs has prompted a new type of transportation logistics problem of finding a fuel‐efficient and quickest path for a call‐taxi through a city road network, where the travel times are stochastic. The stochastic travel time of the road network is induced by obstacles such as the traffic signals and intersections. The delay and additional fuel consumption at each of these obstacles are calculated that are later imputed to the total travel time and fuel consumption of a path. A Monte‐Carlo simulation‐based approach is proposed to identify unique fuel‐efficient paths between two locations in a city road network where each obstacle has a delay distribution. A multi‐criteria score is then assigned to each unique path based on the probability that the path is fuel efficient, the average travel time of the path and the coefficient of variation of the travel times of the path. Copyright © 2016 John Wiley & Sons, Ltd.     

Rule-based control of a semi-active suspension for minimal sprung mass acceleration: design and measurement

In this paper, a rule-based controller is developed for the control of a semi-active suspension to achieve minimal vertical acceleration. The rules are derived from the results obtained with a model predictive controller. It is shown that a rule-based controller can be derived that mimics the results of the model predictive controller and minimises vertical acceleration. Besides this, measurements on a test vehicle show that the developed rule-based controller achieves a real-world reduction of the vertical acceleration, which is in agreement with the simulations.     

Robust control and actuator dynamics compensation for railway vehicles

A robust controller is designed for active steering of a high speed train bogie with solid axle wheel sets to reduce track irregularity effects on the vehicle’s dynamics and improve stability and curving performance. A half-car railway vehicle model with seven degrees of freedom equipped with practical accelerometers and angular velocity sensors is considered for the H_∞ control design. The controller is robust against the wheel/rail contact parameter variations. Field measurement data are used as the track irregularities in simulations. The control force is applied to the vehicle model via ball-screw electromechanical actuators. To compensate the actuator dynamics, the time delay is identified online and is used in a second-order polynomial extrapolation carried out to predict and modify the control command to the actuator. The performance of the proposed controller and actuator dynamics compensation technique are examined on a one-car railway vehicle model with realistic structural parameters and nonlinear wheel and rail profiles. The results showed that for the case of nonlinear wheel and rail profiles significant improvements in the active control performance can be achieved using the proposed compensation technique.