小半径连续叠合钢箱梁弯桥设计及其受力性能浅析

以某工程立交D、F匝道小半径连续钢箱梁弯桥为例,该桥平面为不规则曲线,介绍其构造特点及空间计算分析方法,采用梁单元及空间板壳单元建模对支反力及强度、刚度等计算并对比分析,供同类桥梁设计参考。     

基于ANSYS的冷却器管板胀接有限元分析

胀接过程中胀管量的合理选取关系到换热器的换热性能和松紧程度。本文运用ANSYS软件对管板进行机械胀接过程的模拟,分两个工况:工况一模拟整个胀接过程,模拟胀接过程中换热管的应力和变形情况;工况二模拟换热管拉脱过程,检验其胀接松紧程度。     

基于冗余信息融合的车辆质心侧偏角估计方法

车辆质心侧偏角是表征车辆横向稳定性的重要参数之一,相关的估计方法研究可为整车稳定控制提供重要支撑.为提高车辆质心侧偏角估计效果,提出了一种基于冗余信息融合的质心侧偏角估计方法.分别建立了车辆动力学模型和运动学模型,利用容积卡尔曼滤波算法分别设计了用于车辆行驶状态估计的动力学模型估计器和运动学模型估计器,同时,分析了动力...     

ZPW-2000A智能诊断系统在佛肇城际肇庆站的运用探讨

通过ZPW-2000A轨道电路室外监测及智能诊断系统在肇庆站的运用,结合现场实际测试,提出测试方法,分析系统存在优势和改进意见,为后续进一步推广使用提供参考。     

人之为人:人类学差异还是范畴差异

进化心理学号称是一门关于人性的科学,却无法解释人类为何由于具备了理性能力而有别于其他动物。尽管托马塞洛和帕品纽这样的进化自然主义者试图通过刻画理性的起源及其认知架构来回答这个问题,但是这种"人类学差异"进路不仅自身难以成立,更严重的是它面临着波义尔关于理性的"范畴差异"解释的竞争。根据亚里士多德对"本质"和"形式"的阐述,理性不是指人类拥有某些动物所缺乏的认知机制,而是指改变我们一切既有的基本心理能力从而决定"人之为人"的方式,这种人类心灵的理性能力在康德关于"我思"的理论中有过很好的阐释。本文论证指出,理性的"范畴差异"在诸多方面优于"人类学差异"进路。     

浅析BIM于道路工程中的应用及现状

道路工程对其项目当地周边有着带动经济、 改善民生和传播文化等积极影响, 但同时施工阶段对周边也有着一定消极因素。 BIM 作为一个新兴技术将成为未来设计理念的主流趋势之一, 这种涵盖工程全生命周期的信息集合体将不断挑战传统的设计理念。     

SURVEY SUBAXIAL CERVICAL VERTEBRAE FOR TRANSPEDICULAR SCREW FIXATION

Therearemanycausesofsubaxialcervicalinstabilitysuch astrauma,degenerativedisease,neoplasm,andinfection.Therearenumerousinternalfixationproceduresthathavebeen usedforone stageposteriordecompressionandstabilizationof thecervicalspine.Recentlydevelopedposteriorplatescrew fixationprocedureshavebeenperformedinthecervicalspine byusingalateralmassscreworapediclescrewformal stage posteriordecompressionandstabilizationofthecervical spine[1].Theseveralpotentialrisksofneurovascularcomplica tions,whichare…     

从词汇层面上看语言教学中的文化输入

本从化与语言的关系谈起，说明化输入在语言教学中的重要性。然后以汉英词汇的含义、范围异同来着重谈词汇层面上的化内涵，指出在教授词汇时化因素不可疏忽，提出以新角度看待化教学，提倡词汇层面上的化输入。     

The β-amyloid protein induces S100β expression in rat hippocampus through a mechanism that involves IL-1

Objective To explore the effect of β-amyloid protein (Aβ) on S100β expression in rat hippocampus and its mechanisms. Methods At 7 days after bilateral stereotaxis injection of different dose of fibrillar Aβ 25-35 and interluekin-1 receptor antagonist (IL-1ra) into the rat CA1 region, the learning and memory abilities of rats were tested with passive avoidance task. Amyloid deposition was detected by using Congo red staining technique. Nissl staining and immunohistochemical techniques were used to analyze the number of neurons, and GFAP and the S100β expression in hippocampal CA1 region , respectively. Results After fibrillar Aβ injection, the step-through latency of rats was significantly shortened compared to that of the control group. The GFAP positive astrocytes were found surrounding amyloid deposition. Neuronal loss occurred in the pyramidal cell layer of CA1 region. The number of S100β positive cells in Aβ-treated group was significantly increased compared with that in the control group. After IL-1ra injection, the number of S100β positive cells was significantly decreased. Conclusion Intrahippocampal injection of Aβ 25-35 could cause similar pathologic changes of Alzheimer's disease. Aβ 25-35 was capable of up-regulating S100β expression in a dose-dependent manner. The injection of IL-1ra could attenuate the effect of Aβ on S100β expression.     

PROLIFERATION AND MIGRATION OF EPENDYMAL CELLS IN THE BRAIN OF ADULT RATS AFTER PERMANENT FOCAL CEREBRAL ISCHEMIA

Objective Ependymal cells are thought to be the primary source of neural stem cells in the adult central nervous system. The purpose of this study is to examine spatial and temporal profiles of ependymal cell proliferation and migration after focal cerebral ischemia. Methods Eighty male Sprague Dawley rats underwent permanent middle cerebral artery occlusion after injection of 10/μL of 0.2% Dil into the lateral ventricle. Rats were sacrificed and brain sections were acquired for pathological evaluation and laser confocal imaging at day 1,3,7,11,14,21 and 28 after ischemia. Results The density of Dil-labeled cells in the ischemic ipsilateral subventricular zone was significantly higher than that in the control group and these labeled cells dispersed in the ischemic ipsilateral subventricular zone and/or were located in ependyma from day 1 to 11. In the ischemic ipsilateral cortex, some Diilabeled cells occurred in peri-infarction and infarction of parietal region at day14 and peaked at day 21 when some Dil-labeled cell nodules were found in this region. During postischemic day 14--28, a significant decrease in labeled celldensity in the ischemic ipsilateral subventricular zone was coincident with a significant increase in labeled cells density in the cortex (peri-infarction and infarction). Conclusion The results indicate that ependymal cells proliferate and migrate after focal cerebral ischemia in the adult rat brain.