城轨构架侧梁下盖板自动组焊工艺研究

阐述了某车型城轨构架侧梁下盖板自动组焊工艺的特点、难点,着重分析了下盖板组成结构特点、工装夹具、组焊过程控制等对下盖板组成焊后尺寸、焊缝质量的影响,并通过对焊缝外观检验、探伤检验、宏观金相试验及下盖板组成焊后尺寸检验,对下盖板组成自动组焊工艺研究进行验证。     

集落刺激因子治疗他巴唑致粒细胞缺乏症疗效观察

目的　探讨他巴唑致粒细胞缺乏症 (简称粒缺 )的更有效的治疗方法。方法　回顾性分析比较了本院十余年来收治的2 9例因服他巴唑而致粒缺患者用不同治疗方法的效果。 2 9例中 ,男 4例 ,女 2 5例。年龄 2 5～ 6 0岁。所有患者服他巴唑前血白细胞均正常。病史中无放射线、毒物、化学和其他药物接触史。既往无其他引起白细胞减少的疾病。 2 4例 (82 .8% )服他巴唑≥ 30mg·d-1,5例 (17.2 % )服他巴唑 2 0mg·d-1。 2 9例粒缺出现于服他巴唑后 2～ 2 2周 ,平均 (7.72± 4 .2 7)周 ,其中 2 3例 (79.3% )发生在服药后 4～ 12周。粒缺发生后均行骨髓穿刺 ,骨髓像均呈现粒系细胞增生低下 ,其中 2 5例 (86 .2 % )中幼粒阶段以下显著减少 ,4例 (13.8% )各阶段粒细胞几乎找不到 ,红系和巨核系大致正常。粒缺发生后立即停用他巴唑 ,隔离防护 ,大量广谱抗生素防治感染及其他对症支持治疗基础上 ,加用升白细胞药物。根据所用升白细胞药物不同 ,分为两组。组 1:共 18例 ,口服升白细胞药物 (利血生、鲨甘醇、维生素B4等 ) ;组 2 :共 11例 ,重组人粒细胞集落刺激因子(rhG CSF) /重组人粒 巨噬细胞集落刺激因子 (rhGM CSF) (惠尔血、吉姆欣、生白能 ) ,15 0～ 30 0 μg·d-1,皮下注射 ,每 1～ 2d复查血常规 ,白细胞恢复正?     

THE EFFECT OF FCγ RECEPTOR ON THE PATHOGENESIS OF GRAVES'' DISEASE

Objective To explore the roles of Fcγ receptor in the pathogenesis of Graves' disease. Methods Fcγ receptor gene knockout mice(Fcγ R KO mice) which were rooted in C57BL/6 mice and wild type C57BL/6 mice were immunized by hTSH receptor expressing cells (DAP3.WT).1-2×107 DAP3.WT cells were peritoneally injected into mice every two weeks for a total of six times.Two weeks after final immunization, mice were killed for measurement of total thyroxine,TRAb and pathological examination.Results The thyroxine level of the immunized Fcγ receptor gene knockout mice was significantly lower than that of the immunized wild type control mice (2.2±0.31 vs.3.32±0.59g·dL-1,P<0.05), but there was no significant difference between immunized Fcγ R KO mice and non-immunized wild type control group.The TRAb levels of the immunized Fγ R KO mice significantly increased compared to those of the immunized wild type mice (21.75±8.21 vs.14.11±6.21, P<0.05). The lymphocyte cells infiltration and destruction of thyroid follicles were found in the thyroid gland of the immunized Fcγ R KO mice. Conclusion　These results suggest that Fcγ receptor may be involved in the pathogenesis of Graves'disease.     

THE EFFECT OF FCγ RECEPTOR ON THE PATHOGENESIS OF GRAVES'''' DISEASE

Graves diseaseisanorganspecificautoimmunediseasewhichismainlycausedbyhumoralresponse .Anti TSHreceptorantibodyisoneofthemostim portantfactorsthatcausethe physiopathologicchangeofthiskindofdisease .RecentstudiesofvariousFcreceptorgeneknockoutmice (FcRKOmice)haveprovidedstrongevidencethatFcrecep tors (FcR) playedcrucialrolesinmanyautoimmunediseases ,suchasauto antibody dependentexperi mentalhemolyticanemiaandthrombocy topenia[1- 3] .Inthepresentstudy ,wetriedtoex ploretheroleofFcγreceptoro…