DF8B型机车逻辑控制单元设计

从DF8B LCU功能需求出发，介绍了MVB与CAN总线两种通信网络特点，并对其性能进行比较，重点是MVB方案的LCU功能、硬件系统组成及软件设计。DF8B LCU简化了机车线路，提高了系统可靠性，完全满足机车性能要求。     

Effects of RE on the Microstructure of Mg-SZn-4Al Magnesium Alloys

The effects of RE on the microstrcture of as-cast Mg-8Zn-4Al magnesium alloys were investigated. The results show that the solidification range of Mg-8Zn-4Al-xRE alloys increases with RE additions. A binary eutectic reaction can arise and produce a new phase （Mg：Al：Zn：RE） and the temperature of phase transformation point of the new phase is 412.85 C. In Mg-8Zn-4Al-1.5RE alloy, a small amount of Mg：Al：Zn：RE phase and ε phases are found besides a（Mg）,φand r phases. Also microstructures of Mg-8Zn-4Al alloys can be refined by addition of 1.5% RE obviously.     

主变压器差动保护装置极性问题的探讨

阐述牵引变电所三相V/v接线牵引变压器差动保护极性的影响因素及其校验方法（微机保护的极性、主变压器的极性和电流互感器的极性3方面）,分析了包西线某牵引变电所主变压器设计和接线的缺陷,提出并验证了三相V/v接线牵引变压器差动保护接线方式的正确性。     

汕头苏埃隧道方案设计关键技术研究

根据汕头苏埃隧道的建设条件,对工程方案设计中的几个技术难点进行研究,并提出解决方案。通过采用"多级分流"理念,实现隧道与北岸4条城市主干道的交通衔接;选择"抛石+排水板"方案解决海域深厚淤泥地层中的围堰设计;8度高烈度震区选择合理的抗震减震措施解决隧道结构抗震;采取双道密封垫和加大密封垫断面的防水设计,满足地震时管片接缝张开量大的防水要求;针对复杂地层,对盾构选型和配置提出建议;对海底凸起进入隧道内的硬岩进行爆破预处理,以降低盾构施工风险。     

Caterham Seven 420R v Porsche 911 GT3 RS

在赛道作为一条经验法则,除非420R在打滑,否则其实它根本没用尽全力。它会转向不足——其实有时还挺有用的,如果你非要找到它的极限并再用力推过头一点点的话;但如果你就是入弯时对前胎要求过高那它就那么有帮助了。Seven之妙处在于驾驶者可以立刻知道当前的情况。你完全可以在入弯到     

快速老化小鼠的学习记忆缺陷及其生化机制

目的用快速老化小鼠(SAMP8)模拟老年痴呆,观察其学习记忆能力,并探讨其学习记忆能力下降的可能机制。方法采用10月龄SAMP8,并用同龄抗快速老化小鼠(SAMR1)作为正常对照。用水迷路检测近记忆以及空间学习记忆能力。用生物化学方法检测大脑皮层线粒体膜电位和ATP酶活力,观察线粒体功能;检测皮层和海马胆碱乙酰基转移酶(ChAT)和乙酰胆碱酯酶(AChE)的活力,观察中枢胆碱能神经功能;检测血清超氧化物歧化酶(SOD)活力和丙二醛(MDA)含量,观察其全身性氧化应激状况。结果与SAMR1相比,SAMP8出现明显的衰老体征,其近记忆和空间学习记忆能力明显减弱,具有衰老和痴呆特征;皮层线粒体膜电位和ATP酶活力显著降低,海马ChAT活力显著下降,AChE活力显著升高,血清SOD活力稍有增高。结论SAMP8可以很好地模拟老年痴呆,其机制包括大脑皮层线粒体功能降低、海马胆碱能神经功能下降以及氧化应激等。     

Role of candesartan against cerebral ischemia and oxidative damage in normotensive rats

Objective Angiotensin Ⅱ (Ang Ⅱ ) contributes to modulating blood pressure by stimulation of Ang Ⅱ AT1 receptors. We devised a rat transient middle cerebral artery occlusion (MCAO) model to assess whether oxidative damage is decreased after pretreatment with Angiotensin Ⅱ AT1 receptor blocker (ARB). Methods After 2 weeks pretreatment with ARB 0. 5 and 1 mg/kg, the male Wister rats were subjected to 2 h middle cerebral artery occlusion (MCAO). At 24 h, the lumen diameter of middle cerebral artery, the plasma level of 8-hydroxy-2'-deoxyguanosine (8-OHdG), and HIF-1 a levels were recorded and compared. Results After pretrcatment with ARB 0.5 and 1 mg/kg, blood pressure did not significantly change compared with that of controls. In the group of candesartan at 1 mg/(kg· day), the lumen diameter was significantly increased compared to that in control group [(86.0±5.0) μm vs. (69.0± 2.1) μm; P<0. 01, n = 6- 8]. The plasma 8-OHdG levels of ARB pretreatment groups were decreased. In immunohistochemical findings, 8-OHdG- and HIF-1α-containing cells in ARB pretreatment groups were decreased. Conclusion Brain ischemia and oxidative damage can be reversed by AT1 receptor blockade in normotensive rats after transient cerebral artery occlusion.     

The role of interleukin-8 produced by tumor induced fibroblasts in the development of cutaneous melanoma

Objective To determine the role of interleukin-8 (IL-8) produced by tumor induced fibroblasts in the development of cutaneous melanoma. Methods B16 melanoma cells induced L929 fibroblasts phenotype was transdifferentiated to myofibroblasts (MF) by co-culture in vitro. MF was monitored by morphology and immunophenotype for a-SMA. The level of IL-8 was detected by ELISA. The effect on B16 cell proliferation rate was estimated using MIT method in vitro. Melanoma implanting model was constructed in C57 mice. Results L929 MF phenotype could be modulated by B16 melanoma cells-derived transforming growth factor-β1 (TGF-β1) and elevated the levels of IL-8. L929 MF did not influence the B16 melanoma cells viability in vitro, but shortened the time of tumor formation and increased the incidence rates of tumors in C57 implanting model mice. Conclusion Fibroblasts can be activated by tumor cells and produce IL-8, which acts as an inflammatory cytokine promoting the development of cutaneous melanoma.     

弥漫性轴索损伤后CD4~+/CD8~+ T细胞比值、IL-6、IL-10水平变化及预后相关危险因素的Logistic回归分析

目的研究弥漫性轴索损伤(DAI)后患者外周血CD4+/CD8+T细胞比值及炎症因子IL-6、IL-10水平的变化,探讨影响DAI患者预后的相关危险因素及可能的预测因子。方法收集115例DAI患者的相关临床资料及伤后至少6个月的随访结果,并将采集的患者外周血采用流式细胞仪检测CD4+、CD8+T细胞及其比值,ELISA法检测IL-6、IL-10水平,对免疫炎症指标及临床资料进行单因素和多因素分析,多因素分析采用Logistic回归分析。结果DAI后合并其他脑损伤、瞳孔改变、伤后昏迷时间及入院时GCS评分是影响患者预后的危险因素,而其他因素则与预后不相关。CD4+/CD8+T淋巴细胞比值降低是DAI后发生ARDS/ALI的危险因素,CD4+/CD8+T淋巴细胞比值与患者预后关系不大,而ARDS/ALI的发生则是影响DAI患者预后的重要危险因素。IL-6增加与DAI后ARDS/ALI密切相关,可作为ARDS/ALI发生的预测因子,其水平是患者预后的危险因素,而IL-10则在此过程中与ARDS/ALI不相关,且与患者预后无关。结论 CD4+/CD8+T淋巴细胞比值降低是DAI后发生ARDS/ALI的危险因素,IL-6可作为ARDS/ALI发生的预测因子。DAI后与患者预后相关的危险因素包括合并其他脑损伤、瞳孔改变、伤后昏迷时间、入院时GCS评分、IL-6水平及并发ARDS/ALI。     

城市干道系统交通事故预测模型研究

以哈尔滨市干道路网为研究对象,收集到了该路网上468个路段和163个平面交叉口的道路交通数据,以及1999年至2004年所发生的8510起交通事故数据.分析了事故数据的统计分布特性,应用聚类分析技术确定了路段和交叉口的类别 ,并在此基础上分别建立了事故总体和分事故形态的预测模型.论文探讨了高峰时段的事故次数、事故率与路段v/c之间的定量关系.标定出了24个模型,并形成干道系统事故预测模型库.最后,运用所建立的事故预测模型选取了2010年哈尔滨规划路网的一部分进行实例分析,结果表明了预测模型是有效的.