恒磁场对人脐动脉血管平滑肌细胞胞浆游离钙离子浓度的影响

目的 研究恒磁场对培养的人脐动脉血管平滑肌细胞(VSMC)胞浆内游离钙离子浓度([Ca2 ]i)的影响,探讨恒磁场抑制VSMC增殖的作用机制.方法 离体培养人脐动脉VSMC,不同强度的恒磁场垂直作用于VSMC,应用激光共聚焦显微镜观察恒磁场对VSMC胞浆[Ca2 ]i的影响.结果 5 mT的恒磁场作用于VSMC后10-50 min[Ca2 ]i较对照组明显下降,20 min下降最明显;其平滑肌细胞的Ca2 荧光强度明显弱于对照组,至60 min接近对照组.结论 恒磁场对VSMC胞浆[Ca2 ]i有明显降低作用,可能是抑制VSMC细胞增殖的机制.为经皮冠状动脉成型术(PTCA)术后再狭窄的治疗提供了新的理论基础.     

机动车闯红灯行为影响因素分析

信号控制交叉口由闯红灯引起的交通事故具有较高的伤亡率。为深入了解闯红灯行为的影响因素,利用人工记录与视频观测结合的方法对上海市4个信号控制交叉口进行调查。基于流行病学影响因素研究方法选择未闯红灯行为作为对照组与闯红灯行为对比,以排除无关因素。对调查数据进行行为编码,考虑到各个交叉口的异质性,基于随机效应逻辑斯特模型在交叉口层面分析驾驶环境、驾驶人特点、车辆特征对闯红灯行为的影响。结果表明,本地驾驶人、男性驾驶人、客车更容易闯红灯,流量大会增加闯红灯的可能性;此外,是否为本地车辆、车内是否有乘客对闯红灯行为也有显著影响。     

Therapeutic efficiency of short anterior urethral stricture treated with endourethral surgery combined with iridium 192 radiotherapy

Objective To assess the therapeutic efficiency of short anterior urethral stricture treated with endourethral surgery combined with iridium 192 radiation therapy in order to decrease the recurrence rate after endourethral surgery. Methods A total of 286 patients with anterior urethral stricture (stricture length ranging from 0.5 to 2.5cm, averaging at 1.6cm) were divided randomly into two groups after internal urethrotomy and cicatrix electrotomy. The radiation group of 173 patients was treated as soon as possible with iridium 192 radiation therapy on the stricture sections while the control group of 113 patients was not. The recurrence rate was compared between the two groups during one year's follow-up. Results Among all the 286 successful operations, stricture recurred in 19 patients of the radiation group (recurrence rate of 10.98%) and in 62 ones of the control group (recurrence rate of 54.86%), with a significant difference (P=0.003). Conclusion It is an effective way to prevent recurrence by treating patients as early as possible with iridium 192 radiation on the stricture sections after endourethral operation on anterior urethral stricture.