| SUPPRESSION OF ANGⅡ AFTER ACUTE SALINE LOAD ASSOCIATED WITH THE CHANGES OF PLASMA ANP AND SODIUM METABOLISM IN SALT-SENSITIVE HYPERTENSION PATIENTS |
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| 引用本文： | 王永兴,刘治全,刘艳,侯嵘,叶涛.SUPPRESSION OF ANGⅡ AFTER ACUTE SALINE LOAD ASSOCIATED WITH THE CHANGES OF PLASMA ANP AND SODIUM METABOLISM IN SALT-SENSITIVE HYPERTENSION PATIENTS[J].西安交通大学学报(英文版),2003,15(1). |
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| 作者姓名： | 王永兴 刘治全 刘艳 侯嵘 叶涛 |
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| 作者单位： | Department of Cardiology，Department of Cardiology，Department of Cardiology，Department of Cardiology，Department of Cardiology First Hospital of Xi'an Jiaotong University，Xi'an 710061，China，First Hospital of Xi'an Jiaotong University，Xi'an 710061，China，First Hospital of Xi'an Jiaotong University，Xi'an 710061，China，First Hospital of Xi'an Jiaotong University，Xi'an 710061，China，First Hospital of Xi'an Jiaotong University，Xi'an 710061，China |
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| 摘 要： | Saltsensitivityisanintermediategenotypeofessentialhypertension ,associatedwithnumerousneuro hormonalabnormalities1,12 ] .Theregulationdysfunctionofrenin angiotensinsystemisinvolvedinsaltsensitivity ,whichconsistsoftwodifferentregulatoryresponses ,modulatorsandnon modula tors,aftersaltload2 ,13 ] .Basedonour previousstudies ,theobjectofthisstudyistoinvestigatethechangepatternofrenin angiotensinandatrialnatri ureticpeptide(ANP)ofsaltsensitivehypertensionthroughobservingthechangesinplasmaangio…
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| 关 键 词： | angiotensinⅡ hypertension salt sensitivity modulator non modulator atrial natriuretic peptide |
SUPPRESSION OF ANGⅡ AFTER ACUTE SALINE LOAD ASSOCIATED WITH THE CHANGES OF PLASMA ANP AND SODIUM METABOLISM IN SALT-SENSITIVE HYPERTENSION PATIENTS |
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| Wang Yongxing,Liu Zhiquan,Liu Yan Hou Rong,Ye Tao.SUPPRESSION OF ANGⅡ AFTER ACUTE SALINE LOAD ASSOCIATED WITH THE CHANGES OF PLASMA ANP AND SODIUM METABOLISM IN SALT-SENSITIVE HYPERTENSION PATIENTS[J].Academic Journal of Xi’an Jiaotong University,2003,15(1). |
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| Authors: | Wang Yongxing Liu Zhiquan Liu Yan Hou Rong Ye Tao |
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| Institution: | Department of Cardiology, First Hospital of Xi'an Jiaotong University,Xi'an 710061,China |
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| Abstract: | Objective To observe the changes of plasma AngⅡ,ANP and their relationship with urine sodium excretion in salt sensitive hypertension. Methods The salt sensitivity was determined by acute saline loading test in 173 primary hypertensives of Stage Ⅰ or Stage Ⅱ. Plasma AngⅡand ANP was determined by radioimmunoassay. Results After acute salt load, AngⅡ was suppressed inadequately. The plasma ANP secretion was not increased. The urine sodiun excretion was delayed, Na+ in RBC was increased in salt sensitive subjects. The plasma ANP was decreased in the salt sensitive subjects without AngⅡ suppressed. The 24 hours urine sodium excretion was lower than those AngⅡ suppressed.Conclusion The changes of plasma RAS are not homogeneous after salt load. Those without the plasma AngⅡ suppressed have more severe sodium metabolism abnormalities and the endogenous ANP secretion is impaired in salt sensitive patients. |
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| Keywords: | hypertension salt sensitivity modulator non-modulator atrial natriuretic peptide |
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