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Biocompatibility evaluation of polyethylene terephthalate artificial ligament coating hydroxyapatite by fibroblasts cells in vitro |
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| Authors: | Jia Jiang Wei Hao Yu-zhuo Li Jun Chen Jin-rong Yao Zheng-zhong Shao Hong Li Jian-jun Yang Shi-yi Chen |
| Institution: | 1. Sports Medicine Center, Department of Sports Medicine and Arthroscopy Surgery, Huashan Hospital, Fudan University, Shanghai, 200040, China 2. Laboratory of Advanced Materials, National Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai, 200433, China 3. Department of Bio-Nano Science and Engineering, Key Laboratory for Thin Film and Microfabrication Technology of Ministry of Education, Institute of Micro/Nano Science and Technology, Shanghai Jiaotong University, Shanghai, 200240, China |
| Abstract: | Hydroxyapatite (HA) based materials have been widely used in the field of ligament tissue engineering in the past decades. It has been previously reported that HA can increase the penetration of marrow-derived mesenchymal stem cells (MSCs) and MSCs cells into scaffolds due to increased cell differentiation in biological media. Additionally, it was found that there are much difference between MSCs and anterior cruciate ligament (ACL) cells. For that reason, we mainly evaluate the biocompatibility of polyethylene terephthalate (PET) silk scaffold with fibroblasts cells in vitro. We cultured mouse fibroblasts cells on the substrate of PET fiber and PET-HA scaffold, respectively, and then observed the morphology by using scanning electron microscopy. Our data indicate that PET-HA scaffold has good biocompatibility with fibroblasts cells and can potentially be useful in enhancing the fibroblasts cell differentiation and proliferation. |
| Keywords: | artificial ligament ligamentization hydroxyapatite fibroblasts cells biocompatibility |
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