锌、硒、锗对小鼠免疫功能的影响

用灌胃法观察了微量元素锌、硒、锗对小鼠免疫功能的影响。结果 :锌 (8mg/ kg)、硒 (0 .1mg/kg)、锗 (10 0 mg/ kg)均可显著提高小鼠巨噬细胞吞噬百分率及吞噬指数 ,且加锌组较加锗组的作用更为明显 (P <0 .0 1) ;亦可显著提高小鼠 E-花结形成、淋巴细胞增殖反应和 IL - 6活性 (P <0 .0 1)。各实验组之间无明显差异。提示 :适量的锌、硒、锗可提高机体巨噬细胞吞噬功能 ,增强细胞免疫功能和IL - 6活性。

Effect of zinc, selenium and germanium on the immunity of mice

The immunity of mice was examined after they were given proper zine (Zn), selenium (Se) and germanium (Ge). The results showed that Zn (8mg/kg), Se (0.1mg/kg), Ge (100mg/kg) all could improve phagocytosis rate of macrophagocyte and phayocytosis index of mice, and at the same time, the effect in Zn group was higer than that in Ge group (P<0.01). In addition, Zn, Se, Ge could raise the erythrocyte rosette formation rate (P<0.01), promote lymphocyte transformation rate (P<0.01) and elevate the activity levels of IL 6 (P<0.01), while there were no difference among each group (P>0.05). These results indicate that appropriate Zn, Se and Ge concentration can enhance the immunity of cells.