5-羟色胺转运体基因多态性和抑郁症的发病、性别、严重程度及自杀行为的相关性

目的探讨中国汉族人群5-羟色胺转运体启动区(5-HTTLPR)基因多态性和抑郁症的发病、性别、严重程度及自杀是否相关。方法应用聚合酶链式反应(PCR)扩增技术测定150例抑郁症患者和150例正常对照者的5-HT-TLPR基因型和等位基因,分别验证各种基因型与中、重度抑郁症发病、性别及自杀行为的相关性。结果病例组SS、LS基因型及S等位基因频率均高于对照组(26.0% vs.20.0%;52.7% vs.46.0%;52.3% vs.43.0%;P均<0.05);两组性别分层比较,女性S等位基因频率高于对照组(55.3% vs.43.6%,P<0.05);病例组严重程度分层比较差异无统计学意义(P>0.05);病例组有无自杀行为分层比较,有自杀行为患者SS基因型频率(37.3% vs.20.2%)及S等位基因频率(61.8% vs.47.5%)均高于无自杀行为患者(P<0.05);抑郁自杀组性别分层比较未显示显著性差异(P>0.05);抑郁自杀组病情程度分层比较,重度抑郁自杀者SS基因型频率(42.5% vs.18.2%)及S等位基因频率(68.7% vs.36.4%)均高于中度抑郁自杀者(P<0.05)。结论在中国汉族人群中,5-HTTLPR多态性和抑郁症相关。S等位基因可能是抑郁症的易感基因,特别是女性,SS型可能是抑郁症易感基因型;S等位基因可能是抑郁症患者自杀的危险基因,SS基因型人群可能是抑郁症患者自杀的危险人群,特别是携带S等位基因的重度抑郁症患者更易自杀。     

半潜式钻井平台用钢DH36安定行为试验研究

为了给半潜式钻井平台的安全性和寿命评价提供可靠试验依据,在室温下对半潜式钻井平台用钢DH36钢进行了考虑加载波形、加载速率和应力比影响的多工况单轴棘轮安定试验。结果表明:循环硬化速率随循环周次的增加快速下降,在低于某一值的循环应力作用下,应变将最终趋于棘轮饱和状态;正弦应力波比三角波更快地趋于安定,采用较低的加载速率可以加速材料趋向饱和棘轮状态;峰值应力固定不变时,棘轮应变对应力比历史无明显的记忆性;波形和加载速率对饱和棘轮应变的影响有限,饱和棘轮应变随着应力峰值的增加而增大。     

Within day rescheduling microsimulation combined with macrosimulated traffic

The concept of rescheduling is essential to activity-based modeling in order to calculate effects of both unexpected incidents and adaptation of individuals to traffic demand management measures. When collaboration between individuals is involved or timetable based public transportation modes are chosen, rescheduling becomes complex. This paper describes a new framework to investigate algorithms for rescheduling at a large scale. The framework allows to explicitly model the information flow between traffic information services and travelers. It combines macroscopic traffic assignment with microscopic simulation of agents adapting their schedules. Perception filtering is introduced to allow for traveler specific interpretation of perceived macroscopic data and for information going unnoticed; perception filters feed person specific short term predictions about the environment required for schedule adaptation. Individuals are assumed to maximize schedule utility. Initial agendas are created by the FEATHERS activity-based schedule generator for mutually independent individuals using an undisturbed loaded transportation network. The new framework allows both actor behavior and external phenomena to influence the transportation network state; individuals interpret the state changes via perception filtering and start adapting their schedules, again affecting the network via updated traffic demand. The first rescheduling mechanism that has been investigated uses marginal utility that monotonically decreases with activity duration and a monotonically converging relaxation algorithm to efficiently determine the new activity timing. The current framework implementation is aimed to support re-timing, re-location and activity re-sequencing; re-routing at the level of the individual however, requires microscopic travel simulation.     

波浪中破损船舶的运动响应研究

波浪中破损船舶的运动会同时受到波浪激励和进出水的影响,而船体运动也会影响进出水过程,二者的相互影响机理十分复杂.本文重点研究波浪中破舱进出水对船舶运动响应的影响,文中首先基于势流理论建立了考虑破舱进出水的4DOF(横荡-垂荡-横摇-纵摇)相互耦合时域预报方法,在计算中假设舱内的液面水平,利用修正的伯努利方程模拟破舱进/出水,利用Ikeda's经验公式修正阻尼系数.然后以一艘ITTC破损稳性标模为例,研究了波浪中考虑破舱进出水的数学模型以及破舱进出水对运动响应的影响,并研究了不同自由度、破舱口位置对运动响应的影响.研究表明,本文基于势流理论建立的时域预报方法可以定量的预报破损船舶的运动响应.     

Modeling the behavioral determinants of travel behavior: An application of latent transition analysis

This paper applies the relatively new method of latent class transition analysis to explore the notion that qualitative differences in travel behavior patterns are substantively meaningful and therefore relevant from explanatory point of view. For example, because the bicycle may function as an important access and egress mode, a car user who also (occasionally) uses the bicycle may be more likely to switch to a public transit profile than someone who only uses the car. Data from the Dutch mobility panel are used to inductively reveal travel behavior patterns and model transitions in these patterns over time. Additionally, the effects of seven exogenous variables, including two important life events (i.e. moving house and changing jobs), on cluster membership and the transition probabilities are assessed. The results show that multiple-mode users compared to single-mode users are more likely to switch from one behavioral profile to another. In addition, age, the residential environment, moving house and changing jobs have strong influences on the transition probabilities between the revealed behavioral patterns over time.     

Using automated walking gait analysis for the identification of pedestrian attributes

Collecting microscopic pedestrian behavior and characteristics data is important for optimizing the design of pedestrian facilities for safety, efficiency, and comfortability. This paper provides a framework for the automated classification of pedestrian attributes such as age and gender based on information extracted from their walking gait behavior. The framework extends earlier work on the automated analysis of gait parameters to include analysis of the gait acceleration data which can enable the quantification of the variability, rhythmic pattern and stability of pedestrian’s gait. In this framework, computer vision techniques are used for the automatic detection and tracking of pedestrians in an open environment resulting in pedestrian trajectories and the speed and acceleration dynamic profiles. A collection of gait features are then derived from those dynamic profiles and used for the classification of pedestrian attributes. The gait features include conventional gait parameters such as gait length and frequency and dynamic parameters related to gait variations and stability measures. Two different techniques are used for the classification: a supervised k-Nearest Neighbors (k-NN) algorithm and a newly developed semi-supervised spectral clustering. The classification framework is demonstrated with two case studies from Vancouver, British Columbia and Oakland, California. The results show the superiority of features sets including gait variations and stability measures over features relying only on conventional gait parameters. For gender, correct classification rates (CCR) of 80% and 94% were achieved for the Vancouver and Oakland case studies, respectively. The classification accuracy for gender was higher in the Oakland case which only considered pedestrians walking alone. Pedestrian age classification resulted in a CCR of 90% for the Oakland case study.     

Incorporating human-factors in car-following models: A review of recent developments and research needs

Over the past decades there has been a considerable development in the modeling of car-following (CF) behavior as a result of research undertaken by both traffic engineers and traffic psychologists. While traffic engineers seek to understand the behavior of a traffic stream, traffic psychologists seek to describe the human abilities and errors involved in the driving process. This paper provides a comprehensive review of these two research streams.It is necessary to consider human-factors in CF modeling for a more realistic representation of CF behavior in complex driving situations (for example, in traffic breakdowns, crash-prone situations, and adverse weather conditions) to improve traffic safety and to better understand widely-reported puzzling traffic flow phenomena, such as capacity drop, stop-and-go oscillations, and traffic hysteresis. While there are some excellent reviews of CF models available in the literature, none of these specifically focuses on the human factors in these models.This paper addresses this gap by reviewing the available literature with a specific focus on the latest advances in car-following models from both the engineering and human behavior points of view. In so doing, it analyses the benefits and limitations of various models and highlights future research needs in the area.     

高弯拉强度水泥混凝土早期干缩变形性能研究

主要研究了水泥用量、胶凝材料类型、引气量、砂率等因素对混凝土干缩变形的影响。混凝土试件尺寸采用100 mm×100 mm×515mm,试验在控温控湿箱内进行,通过控温控湿箱的自动调节功能,设定目标温度和湿度过程,湿度按要求自动调节,利用千分表观察试件干湿变形值。湿度变化过程如下:从当前湿度用30 min升到相对湿度99%,恒定180 min,读取初值;用30 min降低湿度到10%,恒定180 min,读取终值;再用30 min升高湿度到99%,恒定180 min,读取初值,如此进行3个循环。试验结果表明:随水泥用量的增加,混凝土早期干缩变形增大;单掺硅灰的混凝土早期干湿变形大,单掺粉煤灰和混掺硅灰与粉煤灰的混凝土差别不大;3 d龄期的混凝土含气量越大,干湿变形也越大;28 d龄期以后,在含气量小于6.8%的情况下,干湿变形随含气量的增加而减小,而当含气量达到10%,干湿变形又呈现增大的趋势。     

新型GFRP组合梁翼缘有效分布宽度分析

利用能量变分法推导出均布线荷载作用下新型GFRP组合梁翼缘有效分布宽度的理论公式,通过有限元数值模拟验证理论公式可靠性。并借鉴传统钢-混凝土组合梁分析方法,对新型GFRP组合梁翼缘有效分布宽度各种影响因素进行了参数分析。     

32 m超低高度混凝土T梁动力性能试验与分析

为了研究开行120km/h货车后既有铁路32m超低高度混凝土T梁的运营状况、安全性和加固对策,选取1孔32m超低高度混凝土T梁进行自振频率、挠度、振幅等主要动力性能测试。结果发现跨中横向振幅超过限值,不能满足120km/h货车运行,需要提高该梁的竖向和横向刚度。