排序方式: 共有30条查询结果,搜索用时 31 毫秒
1.
Objective To explore the risk association of ABCA1-V771M polymorphism with coronary heart disease (CHD) in Hart nationality in Northwest of China. Methods With case-control study, ABCA1-V771M polymorphism was detected in 204 unrelated Hart nationality people in Northwest of China, and all the subjects by coronary angiography were grouped into 106 cases and 98 controls. The genotypes and alleles frequency distribution of ABCA1-V771M polymorphisms were analyzed by PCR-RFLP analysis, and the clinical statistics of serum lipids were compared and its effects of ABCA1-V771M polymorphism on the plasma lipid levels and coronary atherosclerotic heart disease were analyzed. Results The genotypic frequencies of ABCA1-V771M polymorphism matched well under Hardy-Weinberg equilibrium (P>0.05), V and M allelic frequencies were 33.3% and 66.7%. In comparison with VV VM genotype carriers, MM genotypes carriers had much lower plasma levels of HDL-C (P<0. 001) and much higher plasma levels of TG (P<0. 05). M allelic frequency in CHD group was significantly higher than V allelic frequency (P<0. 05). M allele was related with more severity of atherosclerosis in the coronary artery than V allele (P<0.05). However, there was no obvious difference in the incidence of AMI among carriers with three genotypes of ABCA1-V771M polymorphism (P>0.05). Conclusion ABCA1-V771M polymorphism was not only associated with the plasma levels of HDL-C and TG, but also related to the susceptibility and severity of coronary atheroselerotic heart disease. Moreover, M771 allele appeared to be atherogenie among Han population in Northwest of China. 相似文献
2.
3.
4.
5.
文章针对纯电动面包物流车淋雨密封存在的一些漏雨问题,阐述了现状及典型淋雨漏水点,并分析了其漏水原因及进行了优化改善,进一步提高了其一次性淋雨通过率,明显提升了纯电动面包物流车的淋雨密封品质。 相似文献
6.
针对列控中心(TCC)控制的区间方向电路存在的一致性问题,通过采用故障预防、故障控制的方法,对区间方向电路形成闭环的检查,确保区间方向的一致性,在不降低安全性的前提下,提高区间方向电路可用性,减少对铁路运输的影响。 相似文献
7.
8.
挖掘装置是敞口式盾构的重要部件,对敞口式盾构的作业性能起着决定性的作用。以北京市三一重机有限公司研制的首台敞口式盾构挖掘装置为研究对象,利用有限元软件,建立了挖掘装置有限元模型。选取铲斗挖掘模式和伸缩臂挖掘模式进行了强度和刚度分析,得到了挖掘装置的应力云图和位移云图,为敞口式盾构挖掘装置的设计和改进提供参考。对挖掘装置进行了应力测试,对仿真和测试结果进行了比较,验证了仿真结果的有效性。挖掘装置已成功应用于北京地铁6号线2期工程的实际施工中。 相似文献
9.
文章论述了沉管隧道管段临时支承系统的三点支承、四点支承、五点支承等几种主要形式,并进行了分析对比;同时介绍了五点式支承系统在越南西贡东西高速公路过江沉管隧道工程中的应用情况以及支承系统的设计与施工控制。研究结果及工程实践均表明:五点式支承系统在管段安装后始终能保证有三个支承点,可确保管段水下姿态稳定,同时具有更高的安装精度,尤其适合线路长、管段多的沉管隧道。 相似文献
10.
稳心颗粒对家兔3层心室肌细胞瞬时外向钾电流的影响 总被引:1,自引:0,他引:1
目的研究步长稳心颗粒对家兔左心室肌细胞瞬时外向钾电流(Ito)的影响,探讨稳心颗粒抗心律失常的作用机制。方法应用全细胞膜片钳技术,分别记录稳心颗粒组和对照组家兔内层(Endo)、中层(M)和外层(Epi)心室肌细胞的Ito,观察稳心颗粒对家兔心室肌细胞Ito的影响。结果在测试电压+50 mV时,对照组Epi、M和Endo细胞的Ito分别为(4 235.7±953.2)pA(n=11)、(4 115.8±743.1)pA(n=11)和(2 730.2±524.6)pA(n=11),Endo细胞的Ito电流强度明显小于Epi和M细胞(P<0.01);稳心颗粒灌胃给药后家兔左心室肌Epi、M和Endo细胞的Ito电流强度分别为(4 806.4±1 381.8)pA(n=11)、(4 661.3±902.6)pA(n=11)和(4 072.9±1 234.9)pA(n=11),与对照组相比稳心颗粒可明显增加Endo细胞Ito的电流强度(P<0.01)。结论稳心颗粒增加Endo心室肌细胞Ito的电流强度,使心室的跨壁复极离散度(TDR)减小,这可能是其抗心律失常的重要机制之一。 相似文献