儿童慢型克山病的自然病程

为了探讨儿童慢型克山病的自然病程和预后危险因素，本文分析了长期随访的儿童慢型克山病６３例，结果表明：①儿童慢型克山病预后差，其１年存活率５０．５％、５年仅１５．８％；②自然慢性发病、有奔马律、心功能Ⅲ级以上，心电图心室增大，Ｘ线心胸比率重度扩大者，５年存活率低（Ｐ＜０．０５或０．０１）。     

独墩单铰支座曲线梁桥通病分析及治理

针对目前独墩单铰支座曲线梁桥出现的通病 ,就温度对其梁体的变位影响以及预应力等因素对其支座支反力的作用进行了实例剖析。在此基础上探讨此类桥梁的支承体系的病害整治对策 ,并通过加固实例的监测结果予以验证     

海湾大桥北引道沥青混凝土罩面设计

结合广东省汕汾高速公路汕头海湾大桥北引道路面加铺工程,分析软基路段过渡性路面的病害,提出沥青混凝土路面罩面结构设计和施工中须注意的问题.     

水泥混凝土路面质量病害问题探讨

根据目前水泥混凝土路面建设比较普遍的情况,针对施工中出现比较多的质量病害进行了分析,分别从水泥混凝土路面的裂缝产生的过程,材料、配合比、水灰比、施工操作等对质量的影响,以及产生外观质量缺陷的原因进行了评述.     

桥梁单板受力的原因及解决措施

随着交通量的迅猛增长,桥梁单板受力情况越来越频繁,通过对单板受力现象产生原因进行分析,提出解决措施,以供同行参考和借鉴。     

浅析G30线K3981～K3982路段防沙害处治方法

结合博乐公路管理局管养的G30线K3981～K3982路段路基边坡防沙害处治养护项目的实施，对处治沙害实施流程进行了详细的阐述，有一定的参考价值。     

大骨节病病因与发病机制的研究进展及其展望

大骨节病是一种地方性、畸形性骨关节病,至今原因未明,目前以我国西部地区最重,尚无有效治疗措施。本文依据国内外有关研究,总结分析了大骨节病三种病因假说的研究进展及其尚待解决的问题,结合作者及其研究团队近年来的研究进展,提出大骨节病除经典的软骨细胞坏死外还表现有软骨细胞过度凋亡和"去分化",大骨节病软骨细胞差异表达基因、血清蛋白表达谱及短串联重复序列多态性不同于病区内外正常人与骨关节病。确定大骨节病软骨细胞坏死发生的基因与蛋白标志物,以及何种环境因素如何与大骨节病易感基因相互作用而选择性的损伤深层软骨细胞及其干预措施,是未来大骨节病病因发病机制研究的重要目标。     

105国道新丰段加铺水泥砼路面改造探讨

以105国道新丰段路面大修工程为依据,通过对旧路面的调查,分析了水泥砼路面损坏的原因,并采用了对应的处治措施。     

The changes of neuronal activity of the zone incerta in a rodent model of Parkinson＇s disease

Objective To study the changes in neuronal activity of the zone incerta (ZI) following the unilateral lesion of the nigrostriatal pathway. Methods Eiectrophysiological recordings of ZI neurons were made in normal rats and in two groups of rats at different time intervals after injection of 6-hydrodopamine (6-OHDA) into the pars compacta of snbstantia nigra by extracellular recording in vivo. Results The results showed a significant increase in the mean firing rate of ZI during the second and fourth weeks after 6-OHDA lesion [-n=32, (3.6±2. 2)Hz, P<0.001; n=35, (9.3±6.6)Hz, P<0. 001, respectively] compared to that of normal rats [n=39, (9.2±5.2)Hz]. However, no significant change was observed between two groups of 6-OHDA-lesioned rats. With regard to firing pattern, 7.7%(3/39) of ZI neurons discharged regularly, 82.1% (32/39) irregularly and 10. 3% (4/39) in bursts in normal rats. During the second week after 6-OHDA lesion, the regular, irregular and bursting firing neurons recorded in the ZI were 9.4% (3/32), 59. 4% (19/32) and 31.3% (10/32), and during fourth week, the regular, irregular and bursting firing neurons were 14.3% (5/35), 57.1% (20/35) and 28. 6% (10/35), respectively. The firing pattern of the neurons in the three different groups did not change significantly. Conclusion These results suggest that the firing rate of ZI neurons in 6-OHDA-lesioned rats is increased significantly, which may contribute to the pathophysiology of Parkinson's disease.     

Effect of ABCA1-V771M polymorphism on plasma lipid levels and its relationship with coronary atherosclerotic heart disease

Objective To explore the risk association of ABCA1-V771M polymorphism with coronary heart disease (CHD) in Hart nationality in Northwest of China. Methods With case-control study, ABCA1-V771M polymorphism was detected in 204 unrelated Hart nationality people in Northwest of China, and all the subjects by coronary angiography were grouped into 106 cases and 98 controls. The genotypes and alleles frequency distribution of ABCA1-V771M polymorphisms were analyzed by PCR-RFLP analysis, and the clinical statistics of serum lipids were compared and its effects of ABCA1-V771M polymorphism on the plasma lipid levels and coronary atherosclerotic heart disease were analyzed. Results The genotypic frequencies of ABCA1-V771M polymorphism matched well under Hardy-Weinberg equilibrium (P>0.05), V and M allelic frequencies were 33.3% and 66.7%. In comparison with VV VM genotype carriers, MM genotypes carriers had much lower plasma levels of HDL-C (P<0. 001) and much higher plasma levels of TG (P<0. 05). M allelic frequency in CHD group was significantly higher than V allelic frequency (P<0. 05). M allele was related with more severity of atherosclerosis in the coronary artery than V allele (P<0.05). However, there was no obvious difference in the incidence of AMI among carriers with three genotypes of ABCA1-V771M polymorphism (P>0.05). Conclusion ABCA1-V771M polymorphism was not only associated with the plasma levels of HDL-C and TG, but also related to the susceptibility and severity of coronary atheroselerotic heart disease. Moreover, M771 allele appeared to be atherogenie among Han population in Northwest of China.