INHIBITORY EFFECTS OF THE ALKALOIDS FROM Radix Caulophylli ON THE PROLIFERATION OF HUMAN VASCULAR ENDOTHELIAL CELL

Angiogenesisplaysaveryimportantrolein tumorgrowthandmetastasis[1,2].Tumorssignalthe needforabloodsupplybysecretinggrowthfactors thattriggerangiogenesis,includingbasicfibroblast growthfactor(bFGF),vascularendothelialgrowth factor(VEGF)andplatelet deriveden…     

EXPRESSION OF MATRIX METALLOPROTEINASE-2 AND VASCULAR ENDOTHELIAL GROWTH FACTOR IN HUMAN GLIOMA AND THEIR RELATION TO THE INVASION OF THE TUMOR

Neovascularizationcanbeobservedinthe courseoftumorformationandmalignantinvasion,whichwillpromotethemalignantinvasionofthe tumor[1].Vascularendothelialgrowthfactor(VEGF)andmatrixmetalloproteinases(MMPs)are theimportantadjustiveproteinsintheinvasionand neov…     

IDENTIFICATION OF HUMAN MURR1, THE HOMOLOGUE OF MOUSE IMPRINTED Murr1 GENE

Different fromthe biallelic expression mannerof most common autosomal genes,i mprinting is aspecial genomic expression phenomenon,of whichthe i mprinted genes show parental-specific expres-sion only according to their parental origin[1].Cor-rect i mprintingis i mportant inthe nor mal embryon-ic development,postnatal growth,as well as behav-ior of ani mals.Dysregulation of i mprinting hasbeen i mplicated in the pathogenesis of congenitaldiseases and cancer[2-3].To date,78kinds of mousei mprinte…     

THE OPTIMALITY CONDITION AND DUALITY OF MULTIOBJECTIVE POSYNOMIAL GEOMETRIC PROGRAMMING

1IntroductionSinceitsinceptionbyZener[1'2JandDuf-fin[3.'1,geometricprogramminghasundergonerapiddevelopment,especiallyaftertheappear-anceofthefirstbookonthesubject['j.Multiob-jectivemathematicalprogrammingisalsoafast-developingsubject.Therehavebeenmanyachievementsinboththeoreticalandappliedas-pects['~'].Considerthemultiobjectiveprogrammingproblem:whereXcrR"(n>l)isaconstraintsetandf:X-R-(m>2)avectorobjectivefunction.WriteR7=(v6R'lv>o}iandletxbeasdefinedaParetoefficientsolutionof(VMP)ifxeXa…     

THE EFFECT ON PROTEOGLYCAN METABOLISM OF DEOXYNIVALENOL AND SELENIUM IN THE CULTURED HUMAN FETAL CHONDROCYTES IN VITRO

Kashin BeckDisease(KBD)isasevere,en demicosteoarthrosis,butitspathogenesisisstilla pendentproblem.Withregardtoetiologyanalysis,mycotoxinhypothesisandlow seleniumhypothesis havebeenstudiedmoreinChina[1].Thepathologi calfeaturesofKBDarethedegenerationandnec…     

THE EFFECT OF ACUTE MYOCARDIUM ISCHEMIC ON HEART FUNCTION OF PREGNANCY RAT

In recent years,extensive research is underwayto investigate characteristics of coronary heart dis-ease(CHD)among women.Epidemiology has in-dicatedthat sex difference has an obvious presenceinCHD incidence and mortality.Womenprior tomenopause have a muchlower presence inincidenceof CHD[1-2].Whilethe incidence and mortality raterise significantly among post menopausal women orthose who have ovary removed,si milar to that ofsame-age men.It showed that the estrogenlevel hasa close relationshi…     

POLYMORPHISM OF THE vWF LOCUS AND ITS FORENSIC APPLICATION IN COMPACT BONE

Amplifiedfragmentlengthpolymorphisms(Amp--FLPs)havebeenevaluatedasusefulgeneticmarkersinforensiccaseworks{'~'].vWFpolymorphismisoneoftheAmp--FLPsdetectedbythepolymerasechainreaction(PCR).-PopulationdataconcerningvWFhasbeedpreviouslycarriedoutonEuropeanCaucasians[13.ButnodataisavailablefortheChinesepopulation.Inthisreport,wepresentthedataforvWFlocusin112unrelatedChineseHanindividualsanditsapplicabilityincompactboneanddens.MATERIALSANDMETHODS1.PrimersA:5'~ACGTATTCTATTTAT~3…     

INVESTIGATIONS OF THE INFLUENCE OF TAPER CONTAMINATION ON THE FLYING CHARACTERISTICS OF A SLIDER

11ntroductionThesliderfliesovertherotationgdiskinaverylowclearancetohousethetransducercom-pletingthereadandwriteoperationproperly.Itisdisastrousifaslidercrashesdowntherotatingdiskinworkingstate,whichmaycausediskdamagesduetotheseriousfrictionbetweenthesliderandthedisk-Recently,itisdiscoveredthattheslidercrashiscloselyrelatedwiththetapercontamination[l'2'3J.Kurokawa,TakahashiandShinohara[l]believethattheliquefactionofor-ganicgasesonthetapersectionpreventsaparti-clefrompassing,sotheparticlestays…     

ON THE EXISTENCE OF THE h-RESTRICTED EDGE CONNECTIVITY OF A GRAPH

IntroductionLet G=(V,E) be a finite,simple and undi-rected graph with vertex set V and edge set E.We' ll follow the terminology and notation of Ref.[1 ]and terms not defined here can be found inRefs.[1 ,2 ].A set S of edges of G is called an edgedisconnecting set if G - S is disconnected. Theusual edge connectivityλ(G) of G is the minimumcardinality over the all edge disconnecting sets ofG.Note that,in the above definition,absolutelyno conditions or restrictions are imposed either onthe…     

EFFECTS OF CEREBRAL CORTICAL CONCIS ON CELL PROLIFERATION OF THE SUBVENTRICULAR ZONE IN ADULT RATS

Mechanical injuries to the external regions ofthe brain including the cerebral cortex and otherparts of the telencephalon are common yet relativelyuntreatable[1].The predicament in recovery frombrain injury is that the adult central nervous systemis generally thought to be incapable of replacingdead neurons.As the SVZis nowknownto be neu-rogenic andis in close proxi mitytothe cerebral cor-tex and other functionally i mportant forebrain nu-clei,hope has risen that its neurogenesis may be co-op…     

NEURAL NETWORK FOR THE QUANTUM CORRECTION OF NANOSCALE SOI MOSFETS

The study of silicon on insulator(SOI)MOSfield effect transistors(MOSFETs)has been ofgreat interest in recent years[1-2].As the di mensionsof SOI MOSFETs are aggressively scaled into thenanoscale regi me,the inversion carriers shift appar-ently away fromthe interface of Si O2/Si due to thequantumeffect.So it is quite necessary to take thequantumeffect into consideration in SOI MOSFETmodeling and si mulation.The Schr dinger-Poisson(SP)equations subject to an appropriate boundaryc…     

GROWTH DIFFERENTIATION FACTOR-5 STIMULATES THE GROWTH AND ANABOLIC METABOLISM OF ARTICULAR CHONDROCYTES

Growthdifferentiationfactor5(GDF5),also knownascartilage derivedmorphogeneticprotein1(CDMP1),isamemberofthebonemorphogenet icprotein(BMP)familywhichbelongstothe transforminggrowthfactorβ(TGFβ)superfami ly[1].GDF5isarelativelynewmemberofthe BMPfamily.LikeotherBMPs,implantationofre combinantGDF5caninduceectopiccartilagefor mationinmusculartissues.Thephysiologicalrole ofGDF5hasbeenreportedincludingregulationof myogenesis,regulationofchondrogenesis,bone morphogenesis,andneurondifferen…     

THE MORPHOLOGICAL CHANGES IN MUSCLE SPINDLES AND ALTERATIONS IN CELL ACTIVITY OF THE RATS'''' RED NUCLEUS AFTER 2 WEEKS'''' SIMULATED WEIGHTLESSNESS

The extensive negative effects induced by zerogravity or microgravity where offer special environ-ment are har mful for cos monauts[1-3].The real spaceenvironment has many characteristics,including mi-crogravity,electromagnetic fields,and radiation,which may have an effect on the function and mor-phology of the CNS[4],but the changes in CNSin-duced by si mulated weightlessness on the groundcaused the corresponding adaptive changes of cere-bral circulation,which made alterations in sensoryper…     

INVESTIGATION ON THE DYNAMIC RESPONSE PERFORMANCE OF A NOVEL THREE-WAY SOLENOID VALVE

In order to meet the increasinglystrict emissionstandards andi mprove the perfor mance of diesel en-gines,using electronic control systemin diesel en-gines becomes more and more popular.In the com-mon-rail injection system of diesel engines,injec-tion ti ming and injection duration are controlled bythe solenoid valve.The perfor mance of common-rail injection systemis directly deter mined by thesolenoid valve[1-2].A novel high-speed three-waysolenoid valve used in the common-rail injectionsyste…     

THE EFFECT OF FCγ RECEPTOR ON THE PATHOGENESIS OF GRAVES'''' DISEASE

Graves diseaseisanorganspecificautoimmunediseasewhichismainlycausedbyhumoralresponse .Anti TSHreceptorantibodyisoneofthemostim portantfactorsthatcausethe physiopathologicchangeofthiskindofdisease .RecentstudiesofvariousFcreceptorgeneknockoutmice (FcRKOmice)haveprovidedstrongevidencethatFcrecep tors (FcR) playedcrucialrolesinmanyautoimmunediseases ,suchasauto antibody dependentexperi mentalhemolyticanemiaandthrombocy topenia[1- 3] .Inthepresentstudy ,wetriedtoex ploretheroleofFcγreceptoro…     

THE INHIBITORY EFFECT OF MELATONIN ON THE GROWTH OF HUMAN BLADDER CARCINOMA T24 CELL LINE

Melatonin(Mel) ,anindoleamineprimarilyderivedfromthepinealgland ,issecretedduringthehoursofdarkness.Melactsasahormonalconduc tionof photoperiodinfluencedbytheseasonanddailyphysiologicalrhythms.Thefunctionofmelinhumansisobscure .However ,melhasattainedprominenceasatreatmentfordisturbedcircadianrhythmsandsleeppatterns ,hasenhancedthefunc tionofimmunitysystem[1] andhasinhibitedtumorgrowth[2 ] .Thepreviousstudieshaveindicatedthatmelcombinedwithotheranticancerdrugscanin creasetheefficiencyanddecre…     

ONE PROBABLE MECHANISM OF THE LEARNING-MEMORY DAMAGE BY LEAD:THE CHANGES OF NOS IN HIPPOCAMPUS

Leadtoxicityremainsapublicproblemintheworld ,especiallyinthedevelopingcountries.Chronicleadexposurecancauseimpairmentofcog nitivefunctionandsignificantdelaysinbehavioraldevelopment.However ,themechanismsunderly ingtheseimpairmentshavenotbeendefined .Long term potentiation (LTP)isthoughttobeavalidmodeloflearningandmemoryatthelevelofthesynapse[1] .Recently ,nitricoxidesynthase (NOS)hasbeenshowntobeanimportantfactorforforma tionandlastingofLTP[2 ,3 ] .Theremightbesomerelationsamonglead ,LTP…     

DESENSITIZATION OF ACETYLCHOLINE ON THE INHIBITION EFFECTS OF BLOOD PRESSURE IN ANESTHETIZED CANINE

Desensitizationisaphenomenonthatthefirstreactiontowardsadrugdecreasedduringoraftercontinuouslyexposure[1] .Now ,theconceptioniswidelyusedtorepresentthephenomenonthatthereactionoftargettissuesorcellstowardshormone ,drugorneurotransmitterisreduced gradually[2 ] .Themechanismofdesensitizationisstillunclear .Itiswellknownthattheeffectsofheart,autonomicneuralsystem ,muscles ,arefadewhenexposuretoacetylcholine (ACh)foraperiodoftime[3] .Atpre sent,manystudiesfocusonisolatedtissuesorcells[1,5,6 ,7,8]…     

ENHANCING ADHESION OF TETRAHEDRAL AMORPHOUS CARBON FILMS

TheperformanceoftheTACfilmsdeposited bytheFCVAisbetterthanthatofthediamond like carbonfilms[1,2],becausetheformerisofhigher hardnessandtransparency,smallerfriction coefficientandabsorbingtheultravioletraymore easily,etc.[3].Thesecharacteristicsaresimilart…