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Highly porous ultrafine electrospun scaffolds, gelatin/poly(L-lactic acid) (PLLA) and chitosan/PLLA were prepared by blending gelatin and PLLA, chitosan and PLLA respectively. The biocompatibilities of these scaffolds were assessed by attachment, proliferation and viability of cells on them. The results indicated that over 30% WI-38 cells could attach to the gelatin/PLLA and chitosan/PLLA scaffolds at 2 h after seeding, while the attachment of the cells was only 15% on PLLA scaffolds. Both gelatin/PLLA and chitosan/PLLA scaffolds also exhibited a very good ability for proliferation of WI-38 cells. Cell growth on the gelatin/PLLA and chitosan/PLLA scaffolds showed dramatic improvement, indicating a much better biocompatibility in the blends contributed by gelatin and chitosan. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay also demonstrated gelatin/PLLA showed better ability to enhance the growth and functions of the cells. These assays suggest that the electrospun gelatin/PLLA and chitosan/PLLA scaffolds are promising biomaterials with great biocompatibility for the development of skin tissue engineering. 相似文献
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为有效规避隧道内运输危险品的潜在风险,提出一种半开放隧道内易爆危险品运输的风险度量方法.考虑易爆危险品在爆炸时会对周围人员及设施造成伤害,为更好地确定运输的潜在风险源,根据半开放隧道的工程结构特点,基于冲击波理论和事故伤害模型的建模理念,构建风险度量数学模型,并进行风险公理验证.通过算例和敏感性分析,验证新模型的有效性,数据分析结果表明:相较于传统风险度量模型,新模型考虑的因素更全面、计算结果更符合实际情况;新模型对于危险品运输量的敏感度较强,计算结果变化趋势更符合参数的鲁棒变化规律. 相似文献
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为提高我国空中交通管制(简称"空管")的服务质量,弥补现有空管服务质量评价指标体系在构建上的局限性,在原体系的基础上进一步完善了我国空管服务质量评价指标体系。首先,从空管服务过程分析了影响空管服务质量的主要因素。然后,基于质量管理体系中的过程方法和戴明循环理论,建立空管服务质量管理模型。接着,以该模型为基础,选取运行安全、运行效率、管理效能和文化建设四个关键指标,构建了空管服务质量评价指标体系。最后,以厦门空管站的空管服务评价体系指标设置为例,对所建指标体系进行验证。结果表明,该评价体系具有一定的客观性和科学性。 相似文献