洋河大桥灌注桩流沙层旋挖钻成孔工艺

工程概况洋河大桥为张(家口)石(家庄)高速公路张北至旧罗家洼段一座20孔30m大桥,位于冀西北张宣盆地,跨越桑干河支流洋河。桥长608.20m,上部构造为装配式预应力混凝土连续箱梁,下部构造为钻孔灌注桩基础、柱式墩及肋板式桥台,中心桩号K59+773。     

糖皮质激素预处理对兔心肌缺血再灌注损伤的保护作用

目的 探讨糖皮质激素对心肌缺血-再灌注损伤的保护作用.方法 将18只家兔应用冠状动脉左前降支结扎术造成心肌缺血模型,随机分成3组:心肌缺血再灌注损伤模型组(模型组)、糖皮质激素一次大剂量保护组(大剂量组)以及糖皮质激素多次小剂量保护组(小剂量组),每组6只.应用BL-420生物信号采集系统观察记录心电图ST段改变,分别在缺血前、缺血15 min以及再灌注30 min取血测定血浆丙二醛(MDA)浓度;缺血区心肌标本制作冰冻切片,行组织化学染色,观察缺血区琥珀酸脱氢酶活性变化.结果 糖皮质激素的大、小剂量保护组再灌注过程中ST段恢复的时间较短,快于模型组;大剂量组血清MDA水平低于小剂量组(P<0.05),且两组均低于模型组(P<0.01);大剂量组缺血心肌琥珀酸脱氢酶活性高于小剂量组,且两组均明显高于模型组.结论 糖皮质激素对心肌缺血-再灌注损伤可以起到有效的保护作用,一次大剂量的治疗保护效果要好于多次小剂量.     

Protective effect of glutamine pretreatment on ischemia-reperfusion injury of spinal cord in rabbits

Objective To investigate the effect of glutamine (Gln) on the content of reduced glutathione hormone (GSH) and aminoglutaminic acid (Glu) of spinal cord following ischemia-reperfusion injury. Methods Totally 40 healthy adult male rabbits were randomly divided into five groups: sham-operation group (S group), ischemia-reperfusion injury group (I/R group), low-dose glutamine group (L Gln group), median-dose glutamine group (M Gln group) and high-dose glutamine group (H Gln group). After glutamine preconditioning, the model of spinal cord ischemia-reporfasion injury was established according to Zivin's method. The general status of animals was observed and the changes of Jacobs scoring were recorded in each group. Malondialdehydes (MDA), GSH, Glu and superoxide dismutase (SOD) activity in lumbar spinal cord tissues were determined using chemical colorimetry. The neuron number and deviation rate in spinal cord anterior horn were observed histopathologically. Results There was no significant difference between L Gin group and I/R group in behavior scoring, SOD activity, content of MDA and Glu, neuron number and deviation rate of spinal cord (P>0.05); however, there was a significant difference in GSH content of spinal cord (P<0.05). M Gln group and I/R group differed significantly (P<0.05) in behavior scoring, SOD activity, content of MDA, Glu, GSH, neuron number and deviation rate of spinal cord. Between H Gln group and M Gln group, there was no significant difference in behavior scoring, content of MDA and Glu, SOD activity, neuron number and aberration rate in spinal cord (P>0.05), whereas there was a significant difference in SOD activity and Giu content (P<0.05). Conclusion Pretreatment with medium-dose glutamine has a protective effect on spinal cord ischemia-reporfasion injury in rabbits, which may be related to the maintenance of GSH content, increase of SOD activity and reduction of MDA.     

Effect of ulinastatin on hepatic ischemia-reperfusion injury in rats

Objective To investigate the effect of ulinastatin (UTI) on hepatic ischemia-reperfusion injury in rats. Methods Totally 24 adult Sprague-Dawley rats were randomly divided into 3 groups: sham-operated control group (SO group), ischemia-reperfusion group (I/R group) and ulinastatin group (UTI group). Liver in I/R group underwent 1 h of reperfasion after 30 min of ischemia. In UTI group, UTI (2×104 U/kg) was administered to rats 30 min before modeling. The levels of alanine aminotransferase, aspartate aminotransferase and tumor necrosis factor-alpha (TNF-α) in serum were measured and the levels of nitric oxide and malondialdehyde in liver were determined. The histological changes of liver were observed. Results The levels of alanine aminotransferase, aspartate aminotransferase and TNF-α in serum were significantly increased in I/R group compared with those in UTI group (P<0.05). The levels of nitric oxide and malondialdehyde in liver were significantly higher in I/R group than in UTI group (P<0.05).Histological examination of liver indicated that the damages were more severe in I/R group than in UTI group.Conclusion UTI has the ability to inhibit the production of TNF-α and oxyradical, and ameliorate microcirculatory dysfunction in rats with hepatic ischemia-reperfasion injury.     

南宁市永和大桥主桥拱肋的施工技术浅析

钢管混凝土拱桥拱肋的施工方法有多种,文章以主跨计算跨径为346.49m的钢管混凝土拱桥——南宁市永和大桥主桥拱肋的施工过程为例,介绍该桥钢管混凝土桁式肋拱桥拱肋钢结构的制作与安装、钢管内混凝土灌注等关键的工序过程。可供其他大跨径钢管混凝土拱桥拱肋施工参考。     

应用荧光偏振技术研究缺氧再灌注培养血管内皮细胞膜流动性

目的　定量研究缺氧再灌注状态下血管内皮细胞膜流动性。方法　采用荧光偏振法对缺氧再灌注动物模型的培养血管内皮细胞的荧光特征光谱进行对比实验分析 ,并定量观测了缺氧再灌注对培养血管内皮细胞膜流动性的影响以及FDP和CAP的保护功能。结果　缺氧和再灌注不同时段内 ,DPH标记的血管内皮细胞的荧光光谱没有实质性改变 ,荧光强度的曲线斜率变化与对照组趋于一致 ,缺氧再灌注损伤可导致血管内皮细胞膜的荧光各向异性值降低 ,FDP和CAP对缺氧状态的培养血管内皮细胞有显著的保护作用。结论　荧光偏振技术是一种高灵敏和稳定的定量研究血管内皮细胞膜流动性的方法。     

硅烷偶联剂对半柔性路面材料性能增强机理研究

为研究掺加硅烷偶联剂对半柔性路面材料的性能影响规律及作用机理,采用马歇尔稳定度、车辙、低温弯曲、冻融劈裂等试验,测试了添加不同掺量硅烷偶联剂的半柔性路面材料的力学性能与路用性能,并确定硅烷偶联剂的最佳掺量,采用高拍仪等仪器观察硅烷偶联剂基于界面改性原理的微观改性机理。结果表明：随着硅烷偶联剂掺量的增加,半柔性路面的高温性能、低温性能和水稳定性能均发生了不同程度的提高,同时其掺量对性能的影响存在峰值,马歇尔稳定度、动稳定度、弯拉应变与冻融劈裂强度比均在掺量为0.5%左右处达到峰值,超过峰值后性能随掺量增加而下降,最终确定硅烷偶联剂的最佳掺量为0.5%。通过测定连通空隙率和灌注率的变化定量反映界面紧密度,通过对比观察普通半柔性路面材料与硅烷偶联剂最佳掺量下的半柔性路面材料的水泥-沥青界面可明显发现,硅烷偶联剂能够在水泥基灌浆材料与沥青混合料之间发生一系列化学反应,从而通过改变水泥-沥青界面的形态,有效改善水泥-沥青界面稳定度并减少水泥-沥青界面裂缝,结合性能试验,硅烷偶联剂可通过界面优化改善半柔性路面的力学及路用性能。     

钻孔灌注桩施工与质量控制

该文结合惠州大桥南引桥工程钻孔灌注桩施工,从成孔、水下灌注、质量检查等不同阶段介绍了钻孔灌注桩施工工艺、质量控制和实践体会。     

寒冷地区基体沥青混合料空隙率对灌注式复合混凝土路面性能的影响

灌注式复合混凝土的水泥基材料用量取决于基体沥青混合料空隙率的大小,为确定适应于寒冷地区灌注式半柔性路面基体沥青混合料的最佳空隙率范围,通过调整关键筛孔,设计了空隙率范围在18%～35%之间的5种集配,灌浆并进行对比试验,研究结果表明：基体沥青混合料空隙率控制在18%～24%之间的灌注式半柔性路面更适应寒冷地区的抗裂抗冻要求。     

BRT专用车道站台段钢桥面铺装的一种解决方案

BRT专用车道的定点停车位作为铺装的薄弱点,若铺装层的高温动稳定性不足将造成该处形成剪切推移、车辙等病害。以贵阳市中环路为背景,对BRT专用车道站台段钢桥面铺装的四个方案进行比选,并选取热拌式沥青混凝土作为实施方案,经验证效果良好,可为国内外的类似工程提供参考。