羟基喜树碱对人胆管癌QBC939裸鼠移植瘤PS2、COX-2的影响

目的探讨羟基喜树碱对人胆管癌QBC939裸鼠移植瘤的乳癌相关肽(PS2)、环氧合酶-2(COX-2)的影响,分析PS2、COX-2与肿瘤发生、发展的关系。方法建立人胆管癌QBC939细胞株裸鼠皮下移植瘤模型,将30只裸鼠随机分成对照组、羟基喜树碱低剂量组和羟基喜树碱高剂量组,观察移植瘤体生长情况,RT-PCR法检测瘤体内PS2、COX-2 mRNA表达。结果与对照组比,羟基喜树碱低、高剂量组都可使移植瘤体的PS2 mRNA表达增高;COX-2 mRNA表达降低,且瘤体生长减慢,与对照组比较差异有统计学意义(P<0.01)。结论羟基喜树碱可降低移植瘤COX-2 mRNA表达,增高移植瘤体的PS2 mRNA表达,并使人胆管癌裸鼠移植瘤生长减慢。     

健胃愈疡颗粒对慢性胃炎伴幽门螺杆菌感染胃黏膜PAF、PS2的表达及对上皮细胞凋亡的影响

目的观察健胃愈疡颗粒(JWYY)对幽门螺杆菌相关性胃炎胃黏膜乳癌相关肽(PS2)和血小板活化因子(plate-let activating factor,PAF)表达的变化,并分析其可能的作用机制。方法80例幽门螺杆菌感染慢性胃炎患者随机分为2组,治疗组42例给予健胃愈疡颗粒治疗,对照组38例给予西药三联药物治疗。应用胃镜下活检胃黏膜组织快速尿素酶和Warthin-Starry染色法检测幽门螺杆菌,应用Western blot检测PS2、PAF表达变化。应用末端转移酶介导的dUTP切口末段标记法(TUNEL)检测细胞凋亡。第4周复查胃镜。结果治疗组凋亡指数明显比对照组减少(P<0.05),治疗组总有效率高于对照组(P<0.05)。Western blot检测显示:JWYY颗粒可上调PS2并下调PAF的表达,而对照组对胃黏膜PS2和PAF的表达影响不大。结论健胃愈疡颗粒治疗幽门螺杆菌(Hp)相关性胃炎可能与杀灭Hp、上调PS2和下调PAF的表达来抑制细胞凋亡有关。     

单相交流逆变系统直流侧电容电压脉动分析

对于单相交流逆变系统,其直流侧电容电压存在固有的2倍于逆变器输出频率的脉动,本文基于基本电路原理对系统暂态过程中电气量的变化规律进行了分析,总结了系统直流侧电容电压脉动的机理,并建立了仿真模型,对系统直流侧电压脉动的相关典型工况进行了分析。     

红色歌谣研究综述

在回顾20世纪80年代中后期以来红色歌谣在历史、文学、传承和人物等领域的研究现状的基础上,提出红色歌谣研究与现实社会生活相互动的方向,实现研究空间拓展,研究方法创新和研究导向的现实介入.     

Collection, spillback, and dissipation in pedestrian evacuation: A network-based method

We present a method of predicting pedestrian route choice behavior and physical congestion during the evacuation of indoor areas with internal obstacles. Under the proposed method, a network is first constructed by discretizing the space into regular hexagonal cells and giving these cells potentials before a modified cell transmission model is employed to predict the evolution of pedestrian flow in the network over time and space. Several properties of this cell transmission model are explored. The method can be used to predict the evolution of pedestrian flow over time and space in indoor areas with internal obstacles and to investigate the collection, spillback, and dissipation behavior of pedestrians passing through a bottleneck. The cell transmission model is further extended to imitate the movements of multiple flows of pedestrians with different destinations. An algorithm based on generalized cell potential is also developed to assign the pedestrian flow.     

Behavior-consistent service substitutions in dynamic environments

In this paper, a novel approach for service substitutions based on the service type in terms of its interface type and behavior semantics is proposed. In order to analyze and verify behavior-consistent service substitutions in dynamic environments, we first present a formal language to describe services from control-flow perspective, then introduce a type and effect system to infer conservative approximations of all possible behaviors of these services. The service behaviors are represented by concurrent behavior expressions （CBEs）. Built upon the interpretation of CBEs, behavior-consistent service substitutions are defined and analyzed by subtyping technology. The correctness of the analysis approach is guaranteed by type safety theorem, which is mechanically proved in the Coq proof assistant. Finally, applications in web services show that our method is effective and feasible.     

8m长低入口城市客车的开发

国内已开发出多种11-12m长的低入口城市客车,而市场需求量大的8m长低入口城市客车还是空白.本文应用轮顶悬架前桥及短后悬结构专利技术,成功开发出低成本的8m长短后悬低入口城市客车.     

舰船物资转运方案计算机辅助决策算法研究

瞬息万变的现代战场对大中型水面战斗舰船甲板物资转运的效率提出越来越高的要求。引入计算机辅助决策技术,在考虑多种牵制因素的情况下,快速获得最优的物资转运方案。详细分析和阐述舰船物资转运线路规划、时间计算、作业排序以及资源配班等4个主要问题的计算机解决方法,为利用计算机辅助制定最优物资转运方案提供可行途径。     

车辆无线电遥控装置自适应波特率的设计和实现

本文介绍了车辆无线电遥控装置自适应波特率的设计和实现,该无线电遥控装置实现了软件自适应修正波特率偏差从而减小无线电遥控装置引入的系统误差和相邻信道的无线电干扰,提高了装置的稳定性,扩大了遥控装置的工作范围。     

桥墩盖梁加固设计与施工探讨

以实际工程为背景，探讨了体外预应力加固桥墩盖梁的方法，经过优化设计采用钢锚梁进行预应力锚固。介绍了钢锚梁的具体构造，采用土木仿真有限元软件模拟分析，对盖梁混凝土承载能力、正常使用和持久状况应力、钢锚梁强度和稳定性进行研究，研究结果验证了加固措施的合理性，探讨了加固施工工艺。