汕头苏埃隧道方案设计关键技术研究

根据汕头苏埃隧道的建设条件,对工程方案设计中的几个技术难点进行研究,并提出解决方案。通过采用"多级分流"理念,实现隧道与北岸4条城市主干道的交通衔接;选择"抛石+排水板"方案解决海域深厚淤泥地层中的围堰设计;8度高烈度震区选择合理的抗震减震措施解决隧道结构抗震;采取双道密封垫和加大密封垫断面的防水设计,满足地震时管片接缝张开量大的防水要求;针对复杂地层,对盾构选型和配置提出建议;对海底凸起进入隧道内的硬岩进行爆破预处理,以降低盾构施工风险。     

京津客运专线悬浇连续梁桥面平整度控制技术

结合京津客运专线悬臂浇筑连续梁的施工过程,介绍了主梁的整体线形及各节段间的接缝控制和桥面横向六面排水坡等平整度控制内容,对全桥合拢后桥面的平整度缺陷处理方法进行了阐述,对今后悬浇连续梁施工中的桥面平整度控制与处理有一定的借鉴作用。     

监控量测在姚村坦隧道施工险情预报中的应用

以景(德镇)婺(源)黄(山)高速公路姚村坦连拱隧道施工中出现的险情为例,结合地表沉降、洞内净空收敛及拱顶下沉进行观测及现场观察,针对隧道出口段围岩失稳导致中导洞右侧工字钢严重内敛现象进行了动态预报,从而为及时采取有效措施排除险情争取了时间,避免了重大事故的发生,以此进一步说明了监控量测在隧道修建过程中的必要性。     

大骨节病病因与发病机制的研究进展及其展望

大骨节病是一种地方性、畸形性骨关节病,至今原因未明,目前以我国西部地区最重,尚无有效治疗措施。本文依据国内外有关研究,总结分析了大骨节病三种病因假说的研究进展及其尚待解决的问题,结合作者及其研究团队近年来的研究进展,提出大骨节病除经典的软骨细胞坏死外还表现有软骨细胞过度凋亡和"去分化",大骨节病软骨细胞差异表达基因、血清蛋白表达谱及短串联重复序列多态性不同于病区内外正常人与骨关节病。确定大骨节病软骨细胞坏死发生的基因与蛋白标志物,以及何种环境因素如何与大骨节病易感基因相互作用而选择性的损伤深层软骨细胞及其干预措施,是未来大骨节病病因发病机制研究的重要目标。     

105国道新丰段加铺水泥砼路面改造探讨

以105国道新丰段路面大修工程为依据,通过对旧路面的调查,分析了水泥砼路面损坏的原因,并采用了对应的处治措施。     

The changes of neuronal activity of the zone incerta in a rodent model of Parkinson＇s disease

Objective To study the changes in neuronal activity of the zone incerta (ZI) following the unilateral lesion of the nigrostriatal pathway. Methods Eiectrophysiological recordings of ZI neurons were made in normal rats and in two groups of rats at different time intervals after injection of 6-hydrodopamine (6-OHDA) into the pars compacta of snbstantia nigra by extracellular recording in vivo. Results The results showed a significant increase in the mean firing rate of ZI during the second and fourth weeks after 6-OHDA lesion [-n=32, (3.6±2. 2)Hz, P<0.001; n=35, (9.3±6.6)Hz, P<0. 001, respectively] compared to that of normal rats [n=39, (9.2±5.2)Hz]. However, no significant change was observed between two groups of 6-OHDA-lesioned rats. With regard to firing pattern, 7.7%(3/39) of ZI neurons discharged regularly, 82.1% (32/39) irregularly and 10. 3% (4/39) in bursts in normal rats. During the second week after 6-OHDA lesion, the regular, irregular and bursting firing neurons recorded in the ZI were 9.4% (3/32), 59. 4% (19/32) and 31.3% (10/32), and during fourth week, the regular, irregular and bursting firing neurons were 14.3% (5/35), 57.1% (20/35) and 28. 6% (10/35), respectively. The firing pattern of the neurons in the three different groups did not change significantly. Conclusion These results suggest that the firing rate of ZI neurons in 6-OHDA-lesioned rats is increased significantly, which may contribute to the pathophysiology of Parkinson's disease.     

Effect of ABCA1-V771M polymorphism on plasma lipid levels and its relationship with coronary atherosclerotic heart disease

Objective To explore the risk association of ABCA1-V771M polymorphism with coronary heart disease (CHD) in Hart nationality in Northwest of China. Methods With case-control study, ABCA1-V771M polymorphism was detected in 204 unrelated Hart nationality people in Northwest of China, and all the subjects by coronary angiography were grouped into 106 cases and 98 controls. The genotypes and alleles frequency distribution of ABCA1-V771M polymorphisms were analyzed by PCR-RFLP analysis, and the clinical statistics of serum lipids were compared and its effects of ABCA1-V771M polymorphism on the plasma lipid levels and coronary atherosclerotic heart disease were analyzed. Results The genotypic frequencies of ABCA1-V771M polymorphism matched well under Hardy-Weinberg equilibrium (P>0.05), V and M allelic frequencies were 33.3% and 66.7%. In comparison with VV VM genotype carriers, MM genotypes carriers had much lower plasma levels of HDL-C (P<0. 001) and much higher plasma levels of TG (P<0. 05). M allelic frequency in CHD group was significantly higher than V allelic frequency (P<0. 05). M allele was related with more severity of atherosclerosis in the coronary artery than V allele (P<0.05). However, there was no obvious difference in the incidence of AMI among carriers with three genotypes of ABCA1-V771M polymorphism (P>0.05). Conclusion ABCA1-V771M polymorphism was not only associated with the plasma levels of HDL-C and TG, but also related to the susceptibility and severity of coronary atheroselerotic heart disease. Moreover, M771 allele appeared to be atherogenie among Han population in Northwest of China.     

Study on T lymphocyte subsets and NK cells in patients with Graves＇ disease combined with type 2 diabetes

Objective To investigate changes in T lymphocyte subsets and NK cells in patients with simple Graves' disease (GD)and Graves' disease combined with type 2 diabetes mellitus (GD/T2DM). Methods Fifteen cases of GD/ T2DM were selected from our hospital from November 2001 to November 2004. Before and after therapy thyroid function, thyroglobulin antibody (TGA), thyroid microsomal antibody (TMA) and blood glucose level were measured, and T lymphocyte subsets (CD3, CD4, CD8, CD4/CD8) and NK cells (CD56) were measured by immunofluorescence double labeling monoclonal antibody and flow cytometry, respectively. At the same time, comparison was made with simple GD (15 cases), T2DM (15 cases) and healthy control (20 cases). Results Before therapy, CD4/CD8, CD4 and NK cells in GD/T2DM were less than normal, and there was no significant difference in comparison with simple GD (P<0.05). In T2DM group, only CD4/CD8 and CD4 were less than those of healthy controls (P<0.05). When thyroid function recovered after 1 to 3 months of methimazole treatment in both GD/T2DM and simple GD groups, various indexes recovered, which were more obvious in simple GD. Conclusion Immune hypofunction of GD may be the key to the immune abnormality of GD/T2DM, which is more significant than that of simple GD or T2DM. The recovery of thyroid function and immune abnormality is not consistent, and the recovery of GD is more significant than that of GD/T2DM.     

探讨沥青路面局部渗水的原因及处理方法

通过武汉市汉蔡高速公路沥青路面出现的局部渗水现象,分析沥青路面产生局部渗水的原因及处理的必要性,提出对沥青路面局部渗水的处理原则及处理方法。     

京珠高速公路隧道病害检测与处治对策研究

通过京珠高速公路隧道病害现场检测,对其主要病害进行了分类统计。考虑该隧道的勘察、设计、施工等因素影响,对该隧道主要病害产生原因进行了分析,在此基础上,对隧道病害等级进行了判定,并针对不同等级病害,提出了具体的处治措施。